“三子水剂”外洗治疗女阴瘙痒症临床疗效观察

Clinical Observation on Topical Washing with Sanzi Lotion for the Treatment of Pruritus Vulvae

【目的】观察“三子水剂”外洗治疗女阴瘙痒症(pruritus vulvae,PV)的临床疗效。【方法】将60例湿热下注型女阴瘙痒症患者随机分为对照组和试验组,每组各30例。对照组给予皮肤康洗液外洗治疗,试验组给予“三子水剂”外洗治疗。7 d为1个疗程,连续治疗4个疗程。观察2组患者治疗前后瘙痒程度、瘙痒频率及继发皮损等症状评分及皮肤病生活质量指数(DLQI)评分的变化情况,并评价2组患者的临床疗效和安全性。【结果】(1)疗效方面,治疗4周后,试验组的总有效率和愈显率分别为96.67%(29/30)、86.67%(26/30),对照组分别为90.00%(27/30)和63.34%(19/30);组间比较,试验组的愈显率明显高于对照组,差异有统计学意义(P<0.05),而总有效率有高于对照组趋势,但差异无统计学意义(P>0.05)。(2)症状评分方面,治疗后,2组患者的瘙痒程度、瘙痒频率、继发皮损等症状评分均较治疗前降低(P<0.05),且试验组对瘙痒程度、瘙痒频率、继发皮损等症状评分的降低作用均明显优于对照组,差异均有统计学意义(P<0.05)。(3)生活质量方面,治疗后,2组患者的DLQI评分均较治疗前明显降低(P<0.01),且试验组对DLQI评分的降低作用明显优于对照组,差异有统计学意义(P<0.05)。(4)安全性方面,治疗期间,2组患者均未出现外阴皮肤不适及过敏反应,且均未发现血常规、肝功能及肾功能等安全性指标的异常变化,具有较高的安全性。【结论】“三子水剂”外洗治疗女阴瘙痒症,具有安全性高、疗效好的特点,能够有效减轻患者瘙痒程度,降低瘙痒频率,缓解继发皮损,有利于提高患者生活质量。

Objective To observe the clinical efficacy of topical washing with Sanzi Lotion in treating pruritus vulvae(PV).Methods Sixty cases of PV female with damp-heat pouring downward syndrome were randomly divided into control group and trial group,30 cases in each group.The control group was given topical washing with Pifukang Lotion,and the trial group was given topical washing with Sanzi Lotion.Seven days constituted a course of treatment,and the treatment for the two groups lasted for 4 consecutive courses.The changes in the scores of the symptoms of itching degree,itching frequency,secondary lesions as well as the Dermatology Life Quality Index(DLQI)scores in the two groups were observed before and after the treatment.After treatment,the clinical efficacy and safety in the two groups were evaluated.Results(1)After 4 weeks of treatment,the total effective rate and the cured and markedly effective rate of the trial group were 96.67%(29/30)and 86.67%(26/30),respectively,while those of the control group were 90.00%(27/30)and 63.34%(19/30),respectively.The intergroup comparison showed that the cured and markedly effective rate of the trial group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).The total effective rate of the trial group tended to be higher than that of the control group,but the difference was not statistically significant(P>0.05).(2)After treatment,the scores of the symptoms of itching degree,itching frequency and secondary skin lesions of the two groups were all decreased compared with those before treatment(P<0.05),and the decrease of the scores in the trial group was significantly superior to that in the control group,the differences being all statistically significant(P<0.05).(3)After treatment,the DLQI scores of the two groups were significantly decreased compared with those before treatment(P<0.01),and the decrease of the scores in the trial group was significantly superior to that in the control group,the difference being statistically significant(P<0.05).(4)During the treatment period,no vulvar skin discomfort or allergic reaction occurred in the two groups,or no abnormal changes in safety indicators of blood routine test,liver function and kidney function were found,which is of high safety.Conclusion The topical washing with Sanzi Lotion has high safety and good efficacy in treating PV,which can effectively decrease the degree of itching and the frequency of itching,alleviate the secondary lesions,and improve the quality of life of the patients.