脑血流自动调节及神经血管耦联机制在颈动脉支架围术期的应用研究进展

Research progress on perioperative monitoring of cerebral autoregulation and neurovascular coupling for carotid artery stenting

脑血流自动调节(cerebral autoregulation,CA)系指在一定血压或脑灌注压波动范围内,通过脑小血管的舒缩功能维持脑血流量(cerebral blood flow,CBF)相对稳定的能力。缺血性脑血管相关疾病可导致脑血流自动调节功能受损,其相关机制尚不明确。针对二者关系的研究是当前热点,CA及神经血管耦联(neurovascular coupling,NVC)在颈动脉支架围术期的监测同样发挥着重要价值。本文主要就CA和NVC在颈动脉支架围术期监测的相关进展做一综述,旨在探讨CA及NVC在颈动脉支架围术期进行脑血流自动调节功能监测的临床应用价值。

Cerebral autoregulation(CA)is the ability of blood vessels to keep cerebral blood flow(CBF)relatively constant across a wide range of blood pressure or cerebral perfusion pressure.Ischemic cerebrovascular disease has been associated with CA impairment,but the mechanism is unclear.While their association is a focus,research on perioperative CA and neurovascular coupling(NVC)monitoring for carotid artery stenting has also made progress.This paper focuses on research progress on perioperative CA and NVC monitoring in patients undergoing carotid artery stenting,and discusses the value of CA and NVC for monitoring autoregulation of cerebral blood flow in the perioperative period of carotid artery stenting.