摘要
人脑具有极为精妙的神经血管功能体系以满足脑细胞对能量代谢刻不容缓的需求。然而,现有的仪器设备仅能探测单一的神经血管功能,导致碎片化认知,许多与神经血管疾病相关的科学问题悬而未决。本文旨在回顾在面对重大疾病时脑血流自动调节功能、脑血管反应性功能、神经血管耦联功能以及自主神经功能等神经血管功能所扮演的角色,并探讨多功能、多范式、高分辨率的人体多模态跨尺度神经血管功能测量系统的可行性,为深入研究脑血管病及神经退行性疾病等重大神经血管疾病的新理论和新机制提供科学工具。
The human brain has an extremely sophisticated neurovascular system to meet the instant demands of energy metabolism for brain cells.However,existing instruments can only detect single neurovascular functions to provide so fragmented information that many scientific issues related to neurovascular diseases remain unresolved.This paper reviews the role of cerebral autoregulation,cerebrovascular reactivity,neurovascular coupling,and autonomic nervous function in major diseases,and discusses the feasibility of a multi-functional,multi-paradigm,multi-scale,and high-resolution measurement system for human neurovascular function.We hope to provide scientific tools for in-depth investigation into new theories and mechanisms of major neurovascular diseases such as cerebrovascular disease and neurodegenerative disease.
作者
刘嘉
张攀登
刘畅
王秋颖
高峰
LIU Jia;ZHANG Pandeng;LIU Chang(Laboratory for Engineering and Scientific Computing,Institute of Advanced Computing and Digital Engineering,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China)
出处
《中风与神经疾病杂志》
CAS
2024年第1期24-30,F0003,共8页
Journal of Apoplexy and Nervous Diseases
关键词
脑血管病
脑血流自动调节
姿态估计与配准
柔性光学半导体材料
神经退行性疾病
Cerebrovascular disease
Cerebral autoregulation
Pose estimation and alignment
Flexible optical semiconductor material
Neurodegenerative disease
