基于临床及影像指标对肺癌患者预后及危险因素的分析

Survival prognosis and risk factors analysis for lung cancer patients based on clinical and imaging indicators

目的:基于临床及影像指标探讨肺癌患者的预后及危险因素。方法:前瞻性分析93例肺癌患者的临床及影像资料,根据预后将其分为生存组75例和死亡组18例。结果:死亡组年龄、男性发病率、吸烟比例均大于生存组,第1秒用力呼气容积占预计值的百分比(FEV1%)、用力肺活量占预计值的百分比(FVC%)、1秒率占预计值的百分比(FEV1/FVC%)均低于生存组,肿瘤确诊时Ⅳ期比例大于生存组,支气管扩张、支气管管壁增厚、肺气肿、肺不张、间质性炎症发生率均高于生存组,主动脉直径、肺动脉直径、肿瘤体积更大,中央型、鳞癌发生率均大于生存组(均P<0.05)。经多因素分析发现,肿瘤分期和FVC%是肺癌患者预后不良的危险因素。结论:肺癌患者生存组和死亡组在多项临床及影像指标方面存在显著性差异,其中肿瘤分期和FVC%是肺癌患者预后不良的危险因素。

Objective:To explore the survival prognosis and risk factors of patients with lung cancer based on clinical and imaging indicators.Methods:The clinical and imaging data of lung cancer patients were collected for prospective analysis.According to the survival and death conditions,93 patients were divided into the survival group(75 cases)and the death group(18 cases).Results:The age,male incidence rate and smoking rate in the death group were higher than those in the survival group,while FEV1%,FVC%,FEV1/FVC%in the death group were lower than those in the survival group.The proportion of stageⅣtumor in the death group was higher than that in the survival group.The incidences of bronchiectasis,bronchial tube wall thickening,emphysema,atelectasis and interstitial inflammation,and aortic diameter,pulmonary artery diameter,tumor volume,incidence of central tumor and squamous carcinoma in the death group were higher than those in the survival group.Multivariate analysis showed that tumor stage and FVC%were the poor prognosis factors.Conclusions:There are significant differences in clinical and imaging indicators between the survival group and the death group,and tumor stage and FVC%are risk factors for poor prognosis in patients with lung cancer.