非酒精性脂肪性肝炎促进原发性肝癌的病因与防治策略

Etiology and prevention strategies of nonalcoholic steatohepatitis in the progression of primary liver cancer

非酒精性脂肪性肝炎(nonalcoholic steatohepatitis,NASH)是导致原发性肝癌的重要致病因素,其发病机制复杂,亟待深入研究。NASH相关的原发性肝癌是代谢性疾病导致的恶性肿瘤典型代表,揭示NASH进展为原发性肝癌的进程及其发病机制,对临床预防和治疗NASH相关原发性肝癌具有重要意义。本文就NASH进展为原发性肝癌的病因及防治策略进行述评,以期为临床研究、治疗提供参考和借鉴。

Nonalcoholic steatohepatitis(NASH)is an important pathogenic factor leading to primary liver cancer.The pathogen-esis of NASH is complex and urgently needed for further study.NASH-related primary liver cancer is a typical representative of malig-nant tumors caused by metabolic diseases.Understanding the process and mechanism of NASH progression to primary liver cancer is of great significance for the clinical prevention and treatment of NASH-related primary liver cancer.This article provided a review of the pathogenesis and treatment strategies of NASH progression to primary liver cancer,and aimed to provide references for clinical research.