肝衰竭营养与肝再生

Nutrition and liver regeneration in liver failure

肝脏是人体重要的消化和代谢器官,有较强的再生潜能。肝衰竭为多种原因造成肝细胞大量坏死导致的严重肝功能失代偿,病死率高,肝再生是肝衰竭救治成功与否的关键因素。目前研究显示肝再生是由多因素精确控制的复杂过程,更为具体深入的机制研究、可用于临床监测的肝再生指标及治疗靶点仍需进一步探索完善。肝衰竭患者普遍存在营养不良,包括多种营养素的摄入及利用障碍。营养不良对肝再生等病理/生理过程具有重要意义,应在肝衰竭的诊断及治疗中充分重视。本文就肝衰竭中的营养与肝再生研究进展做一述评,以期提升临床医护和研究人员的认识和系统理解,为该领域的机制研究、临床诊疗优化提供借鉴与参考,并进一步通过有效的营养干预促进肝再生,提高肝衰竭患者存活率,尤其是非肝移植患者的存活率。

Liver is an important digestive and metabolic organ in the human body with strong regenerative potential.Liver failure is a severe liver function decompensation caused by the massive necrosis of liver cells due to multiple reasons,with a high mortality rate,and liver regeneration is the core and key factor in the treatment of liver failure.Liver regeneration is a complex process precisely controlled by multiple factors,while the related mechanisms,liver regeneration indicators that can be used for clinical monitoring,and treatment targets still need to be further improved.Malnutrition is common in patients with liver failure,and malnutrition,including in-take and utilization disorders of multiple nutrients,is of great significance for the pathological and physiological processes of liver regen-eration.It should be fully valued in the diagnosis and treatment of liver failure,with the aim of promoting liver regeneration through ef-fective nutritional interventions and improving the survival rate of liver failure,especially the non-liver transplantation survival rate.