复方谷氨酰胺肠溶胶囊联合双歧杆菌四联活菌片治疗肠道菌群失调相关性腹泻的疗效

Efficacy of compound glutamine enteric-coated capsules combined with bifidobacterium bifidum tetragonum tablets in the treatment of intestinal flora dysregulation associated diarrhoea

目的观察复方谷氨酰胺肠溶胶囊联合双歧杆菌四联活菌片治疗肠道菌群失调相关性腹泻的疗效。方法选取2022年中国人民解放军陆军第七十三集团军医院收治的肠道菌群失调相关性腹泻患者100例,按双色球法分为双歧杆菌组(n=50)与联合治疗组(n=50)。双歧杆菌组给予双歧杆菌四联活菌片治疗,联合治疗组在双歧杆菌组基础上联合复方谷氨酰胺肠溶胶囊治疗,2组均治疗30 d。比较2组临床疗效,治疗前与治疗30 d后真菌感染、细菌计数减少、杆球比例倒置情况及世界卫生组织生存质量测定量表简表(WHOQOL-BREF)(生理、心理、社会关系、环境)评分、症状(腹胀、排便急迫感、腹痛、腹泻)积分,不良反应。结果联合治疗组总有效率高于双歧杆菌组(96.00%vs.82.00%,χ^(2)=5.005,P=0.025)。治疗30 d后,2组真菌感染、细菌计数减少、杆球比例倒置者占比低于治疗前,且联合治疗组低于双歧杆菌组(P<0.01);2组生理、心理、社会关系、环境评分高于治疗前,且联合治疗组高于双歧杆菌组(P<0.01);2组腹胀、排便急迫感、腹痛、腹泻积分低于治疗前,且联合治疗组低于双歧杆菌组(P<0.01)。双歧杆菌组不良反应总发生率为6.00%,与联合治疗组的2.00%比较,差异无统计学意义(χ^(2)=0.260,P=0.610)。结论复方谷氨酰胺肠溶胶囊联合双歧杆菌四联活菌片治疗肠道菌群失调相关性腹泻可提高临床疗效,改善患者肠道微生物环境,减轻临床症状,提高患者的生活质量,且安全性较高。

Objective To observe the efficacy of compound glutamine enteric-coated capsules combined with bifidobacterium bifidum tetragonum tablets in the treatment of intestinal flora dysregulation associated diarrhoea.Methods A total of 100 patients with intestinal flora dysregulation associated diarrhoea admitted to 73rd Army Hospital of Chinese People′s Liberation Army in 2022 were selected,and they were divided into the bifidobacterium group(n=50)and the combination group(n=50)according to the two-colour ball method.The bifidobacterium group was treated with bifidobacterium bifidum tetragonum tablets,and the combination group was treated with compound glutamine enteric-coated capsules on the basis of the bifidobacterium group,and both groups were treated for 30 days.Clinical efficacy,incidence of fungal infection,bacterial count reduction,rod-ball ratio inversion,and scores of WHOQOL-BREF(physiology,psychology,social relationship and environment),scores of symptom(bloating,urgency of defecation,abdominal pain and diarrhoea)before and after 30 days of treatment,and adverse reactions were compared between the two groups.Results Total effective rate in the combination group was higher than that in the bifidobacterium group(96.00%vs.82.00%,χ^(2)=5.005,P=0.025).After 30 days of treatment,the percentage of fungal infection,bacterial count reduction,rod-ball ratio inversion in the two groups were lower than those before treatment,and the combination group were lower than those of the bifidobacterium group(P<0.01);Scores of physiology,psychology,social relationship and environment of the two groups were higher than those before treatment,and the combination group were higher than those of the bifidobacterium group(P<0.01);Scores of bloating,urgency of defecation,abdominal pain and diarrhoea of the two groups were lower than those before treatment,and the combination group were lower than those of the bifidobacterium group(P<0.01).The total incidence of adverse reactions in the bifidobacterium group was 6.00%,which was not statistically difference compared with 2.00%in the combination group(χ^(2)=0.260,P=0.610).Conclusion Compound glutamine enteric-coated capsules combined with bifidobacterium bifidum tetragonum tablets can improve the clinical efficacy in the treatment of intestinal flora dysregulation associated diarrhoea,it can improve the intestinal microbial environment of patients,reduce clinical symptoms,and improve the quality of life of the patients,and with higher safety.