琥珀酸亚铁口服治疗股骨粗隆间骨折术术后贫血的效果刍议

Discussion on the Effect of Oral Administration of Ferrous Succinate in the Treatment of Postoperative Anemia in Patients with Intertrochanteric Fractures of the Femur

目的 分析琥珀酸亚铁口服治疗股骨粗隆间骨折术(proximal femoral nail antirotation, PFNA)术后贫血的效果。方法 选取2021年1月—2023年2月金湖县人民医院收治的82例PFNA术后贫血患者作为研究对象,利用最新统计学软件生成随机序列后分为研究组和对照组,每组41例。两组患者在PFNA术后均应用维生素C治疗,研究组在术后第1天给于琥珀酸亚铁片口服,对照组不应用促进纠正贫血的药物。分别于术后第1、8天查血细胞分析,比较血红蛋白(hemoglobin, Hb)、血细胞比容(hematocrit, HCT)水平。在术后6个月进行电话随访,对比两组患者的髋关节功能、骨折愈合时间。结果 研究组术后第8天Hb、HCT水平均高于对照组,差异有统计学意义(P<0.001);术后第8天,研究组Hb、HCT水平均高于术前,差异有统计学意义(P<0.05)。研究组Harris评分优良率(97.56%)高于对照组,差异有统计学意义(χ^(2)=8.505,P=0.004)。研究组骨折愈合时间短于对照组,差异有统计学意义(P<0.001)。结论 琥珀酸亚铁对于行PFNA患者的康复具有积极作用,能够改善患者术后的贫血状态,从而促进骨折部位的愈合与髋关节功能的恢复,对于患者的机体康复有重要作用。

Objective To analyze the effect of oral ferrous succinate in the treatment of postoperative anemia after proximal femoral nail antiretrottation(PFNA).Methods A total of 82 patients with post-PFNA anemia admitted to Ji-nhu County People's Hospital from January 2021 to February 2023 were selected as the study objects,and were di-vided into study group and control group using the latest statistical software to generate random sequences,with 41 cases in each group.The two groups of patients were treated with vitamin C after PFNA.The study group was given oral ferrous succinate tablets on the first day after surgery,and the control group was not treated with drugs to promote the correction of anemia.Blood cell analysis was performed on the 1st and 8th day after surgery to compare the levels of Hemoglobin(Hb)and Hematocrit(HCT).A telephone follow-up was conducted 6 months after surgery to compare the hip function and fracture healing time of the two groups.Results The levels of Hb and HCT in the study group were higher than those in the control group on the 8th day after surgery,and the differences were statistically signifi-cant(P<0.001);on the 8th day after operation,the levels of Hb and HCT in the study group were higher than those be-fore operation,and the differences were statistically significant(P<0.05).The Harris score and excellent rate of the study group(97.56%)were higher than those of the control group,and the differences were statistically significant(χ^(2)=8.505,P=0.004).The fracture healing time of the study group was shorter than that of the control group,and the dif-ference was statistically significant(P<0.001).Conclusion Ferrous succinate has a positive effect on the rehabilitation of patients undergoing PFNA,and can improve the postoperative anemia status of patients,thus promoting the healing of the fracture site and the recovery of the hip joint function,and playing an important role in the recovery of the pa-tient's organism.