326例乳腺肿块细针穿刺液基细胞学与石蜡组织病理结果对比

Liquid-based thinprep cytologic test by fine needle aspiration vs histopathology of paraffin-embedded breast tissues in 326 patients

目的 对比乳腺细针穿刺液基细胞学(TCT)与石蜡组织病理形态学特征,探讨其临床意义。方法 收集宝鸡市中心医院2019年1月1日至2020年1月1日乳腺肿块患者321例,所有乳腺包块术前进行细针穿刺、TCT制片,术后与组织石蜡结果对比,形态学特征进行分析。结果 乳腺细针穿刺TCT的特异度(97%)、准确率(98%)较高,漏诊率(1%)及误诊率(3%)极低,敏感度相对较差(71%),与石蜡组织病理结果比较,差异无统计学意义(P<0.05)。结论 细针穿刺细胞学检查在乳腺肿块中诊断有较高临床价值,减少了手术风险,诊断特异度及准确率较高,漏诊率及误诊率较低。

Objective To investigate the morphological characteristics of breast tissue according to liq-uid-based thinprep cytologic test(TCT)by fine needle aspiration(FNA)vs paraffin-embedding histopathology,and their clinical relevance.Methods A tatal of 326 breast mass patients were selected in Baoji Central Hospital from 1st January 2019 to 1st January 2020.Prior to surgery,all breast masses were subjected to FNA biopsy and cytologic smear preparation for TCT.The findings and cell morphology in TCT were compared with postoperative histopathology of the breast tissue.Results Breast FNA-TCT led to good performance with considerably high specificity(97%)and accuracy(98%),and very rates of missed diagnosis(1%)and misdiagnosis(3%),regardless of a relatively poor sensitivity(71%).Conclusion Fine needle aspiration cytology is of high clinical value in breast masses,which greatly reduces the postoperative risk.