子宫切除术中双侧输卵管切除对患者卵巢功能影响及肿瘤标记物观察

Effects of the bilateral fallopian tube resection during the hysterectomy of patients on their ovarian function and the observation of the tumor marker of the patients

目的:探究子宫切除术中切除双侧输卵管对患者卵巢功能、血清肿瘤标志物的影响.方法:回顾性收集2021年1月-2022年12月本院行全子宫切除术患者120例临床资料,根据双侧输卵管切除与否分为切除组55例与保留组65例.对比两组手术指标、术前术后卵巢功能相关指标[黄体生成素(LH)、雌二醇(E2)、卵泡刺激素(FSH)、抗苗勒氏管激素(AMH)、卵巢窦卵泡数(AFC)]、肿瘤学指标[血清癌抗原(CA)125、CA199、血管内皮生长因子-C(VEGF-C)].结果:两组手术指标无差异(P>0.05),观察组盆腔包裹性积液发生率低于保留组(P<0.05).两组术后3个月LH、FSH水平均上升,E2、AMH、AFC均下降,且切除组E2水平低于保留组(P<0.05).两组术后3个月血清CA125、CA199、VEGF-C水平均下降且切除组(16.20±4.36IU/ml、10.60±3.12IU/ml、165.14±30.24pg/ml)低于保留组(25.83±6.12IU/ml、16.02±4.13IU/ml、200.25±32.38pg/ml)(均P<0.05).结论:子宫切除术中切除双侧输卵管并未加重卵巢功能减退.

Objective:To explore the ffcts of the bilateral fllopian tube resection during the hysterectomy of patients on their ovarian function and serum tumor markers levels.Methods:The clinical data of 120 patients who had underg-one total hysterectomy from January 2020 to Dcember 2022 were ollcted retrospectively.These patients were divided.into 55 cases with bilateral fallopian tube resection in group A and 65 cases with the reserved bilateral fallopian tube in group B according to the bilateral tubal resection during the hysterectomy or not.The surgical indictors,the Preopera-tive and postoperative indicators related to ovarian function.such as luteinizing hormone(LH),estradiol(E_(2))。fllicle stimulating hormone(FSH).anti-Muller's tube hormone(AMH)and antral fllile count(AFC),and the level of oncology indicators,such as the serum cancer antigen(CA)125,CA199,and vascular endothelial growth factors-C(VEGF-C),of the patients were compared between the two groups.Results:There was no significant difference in the surgical indicators of the patients between the two groups(P>0.05).The incidence of the pelvic encapsulated effusion of the patients in group A was significantly lower than that of the patients in group B(P<0.05).In 3 months after op-cration,the levels of LH and FSH of the patients in the two groups had increased significantly,and the levels of E,AMH and AFCof the patients in the two groups had decreased significantly,and the level of E of the patients in group A was significantly lower than that of the patients in group B(P<0.05).The serum levels of CA125,CA199 and VEGF C of the patients in the two groups in 3 months after operation had decreased significantly,and which(16.20±4.36 IU/ml,10.60±3.12 IU/ml and 165.14±30.24 pg/ml)of the patients in group A were significantly lower than those(25.83±6.12 IU/ml,16.02±4.13 IU/ml and 200.25±32.38 pg/ml)of the patients in group B(all P<0.05)。Conclusion:The bilateral fllopian tube resection during hysterectomy of the patients does not aggravate their o-varian hypofunction,and which is of the greater oncology value.