超声血流阻力联合糖类抗原检测诊断子宫内膜癌效果

Efficacy of the blood flow resistance by ultrasound combined with the carbohydrate antigen for diagnosing endometrial cancer

目的:分析超声评估血流阻力特征联合糖类抗原检测对子宫内膜癌的诊断效果.方法:回顾性收集2021年1月-2023年6月本院诊治并确诊的子宫内膜癌患者35例为内膜癌组,子宫内膜良性病变患者21例为良性病变组,体检健康女性56例为对照组.均进行超声检查获得血流阻力相关参数,检测糖类抗原(CA);采用多因素logistic回归分析子宫内膜癌发生危险因素,受试者工作特征(ROC)曲线分析超声评估血流阻力特征联合糖类抗原检测诊断子宫内膜癌效能.结果:低阻力及高低阻力并存比例内膜癌组、良性病变组、对照组依次降低,血清CA125、CA199、CA153水平依次降低(均P<0.05).经多因素logistic回归分析表明,评估血流阻力低、CA125、CA199、CA153水平高为发生子宫内膜癌的独立危险因素(P<0.05).超声血流阻力参数及糖类抗原检测诊断子宫内膜癌的曲线下面积分别为0.734、0.711、0.705、0.722,联合诊断曲线下面积(0.821)提高,且灵敏度(87.5%)、特异度(78.6%)、准确度(83.0%)均高于单一指标检测.结论:超声评估血流阻力特征联合糖类抗原检测辅助诊断子宫内膜癌准确率较高,有一定临床应用价值.

Objective:To analyze the efficacy of the blood flow resistance characteristics evaluated by ultrasound combined with the carbohydrate antigen detection of patients for diagnosing their endometrial cancer.Method:35 women with endometrial cancer diagnosed and treated in hospital from January 2021 to June 2023 were selected in group A retrospectively,and 21 women with benign endometrial lesions were selected in group B.In addition,56 healthy women who came to hospital for physical examination during the same period were included in group C.All the women in the three groups had undergone ultrasound examination to obtain the blood flow resistance related parameters values.The level of carbohydrate antigens(CA)the women in the three groups was detccted.Multivariate logistic regression was used to analyze the risk factors of endometrial cancer occurrence.Rceiver operating characteristic(ROC)curve was used to analyze the diagnostic efficacy of the blood flow resistance characteristics evaluated by ultrasound combined with the CA level of the women for their endometrial cancer.Results:The proportion of the coexistence of blood flow high and low resistance of the women in group A.group B,and group C had decreased gradually,and the serum levels of CA125,CA199,and CA153 of the women in group A.group B,and group C had also decreased gradually(all P<0.05).Multivariate logistic regression analysis showed that the low values of the blood flow resistance and the high levels of CA125,CA199 and CA153 of the women were the independent risk factors of their endometrial cancer occurrence(P<0.05).The area under the curve of the ultrasonic blood flow resistance parameters values and the levels of CA125,CA199 and CA153 of the women for diagnosing their endometrial carcinoma were 0.734,0.711,0.705,and 0.722,respectively.The arca under the curver the sensitivity,the specificity and the accuracy of the combined ultrasonic blood flow resistance parameters values and the CA levels of the women for diagnosing their endometrial carcinoma were 0.821,87.5%,78.6%and 83.0%.respectively,and which were significantly higher than those of the ultrasonic blood flow resistance parameters values or the CA levels.Conclusion:The accuracy of the combined ultrasonic blood flow resistance parameters values and the CA levels of the women for diagnosing their endometrial carcinoma is high,and which has certain elinical application value.