咪达唑仑联合丙戊酸钠治疗癫痫持续状态的效果及安全性分析

Midazolam Combined with Sodium Valproate in the Treatment of Persistent Status Epilepticus:Clinicall Efficacy and Safety Analysis

目的:探讨咪达唑仑联合丙戊酸钠治疗癫痫持续状态的效果及安全性。方法:选取2018年1月—2022年12月宜昌市秭归县人民医院收治的癫痫持续状态患者100例作为研究对象,采用随机数字表法分为对照组与观察组,各50例。对照组应用丙戊酸钠治疗,观察组在对照组基础上应用咪达唑仑治疗。比较两组患者治疗效果及不良反应发生情况。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P=0.001)。观察组不良反应发生率低于对照组,差异有统计学意义(P=0.001)。结论:咪达唑仑联合丙戊酸钠治疗癫痫持续状态的有效性及安全性均较高,建议临床应用并予以推广。

Objective:To explore the clinical efficacy and Safety of midazolam combined with sodium valproate in the treatment of persistent status epilepticus.Methods:100 cases of patients with persistent status epilepticus admitted to Zigui County People's Hospital of Yichang City,Hubei Province from January 2018 to December 2022 were selected as the study subjects,and were divided into the control group and the observation group,each with 50 cases according to the method of randomized numerical table.The control group was treated with sodium valproate,while the observation group with midazolam on the basis of the control group.The Therapeutic effects and the occurrence of adverse reactions of two groups were compared.Results:The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P=0.001).The incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P=0.001).Conclusion:The clinical efficacy and safety of midazolam combined with sodium valproate in the treatment of persistent status epilepticus is good,and can be applied in the practice.