米索前列醇治疗产后出血的效果分析

Analysis of the Effect of Misoprostol on Postpartum Hemorrhage

目的:探讨米索前列醇治疗产后出血的效果。方法:选取2021年1月—2023年1月贵州省人民医院收治的80例产后出血产妇作为研究对象,根据随机数字表法分为对照组和试验组,各40例。对照组给予缩宫素治疗,试验组给予米索前列醇治疗。比较两组治疗效果。结果:试验组止血时间短于对照组,产后2 h、24 h出血量少于对照组,差异有统计学意义(P<0.001)。试验组治疗总有效率高于对照组,差异有统计学意义(P=0.025)。治疗后,试验组C反应蛋白、白细胞介素-8、肿瘤坏死因子-α水平均低于对照组,差异有统计学意义(P<0.001)。治疗后,试验组凝血酶原时间短于对照组,血红蛋白、血细胞比容高于对照组,差异有统计学意义(P<0.05)。结论:米索前列醇治疗产后出血的效果确切,可快速止血,降低患者产后出血量及炎性因子水平,改善其凝血功能。

Objective:To investigate the effect of misoprostol on postpartum hemorrhage.Methods:A total of eighty cases of postpartum hemorrhage treated in Guizhou Provincial People's Hospital from January 2021 to January 2023 were selected as research objects and divided into control group and experimental group according to random number table method,with forty cases in each group.The control group was treated with oxytocin and the experimental group was treated with misoprostol.The therapeutic effect of the two groups was compared.Results:The hemostatic time of experimental group was shorter than that of control group,and the postpartum blood loss at 2 h and 24 h was less than that of control group,the difference was statistically significant(P<0.001);The total effective rate of experimental group was higher than that of control group,and the difference was statistically significant(P=0.025);After treatment,the levels of C-reactive protein,interleukin-8 and tumor necrosis factor-αin experimental groups were lower than those in control group,with statistical significance(P<0.001);After treatment,the prothrombin time of experimental group was shorter than that of control group,and the hemoglobin and hematocrit of experimental group were higher than that of control group,the difference was statistically significant(P<0.05).Conclusion:The effect of misoprostol in the treatment of postpartum hemorrhage is accurate,can quickly stop bleeding,reduce the amount of postpartum bleeding and the level of inflammatory factors,and improve the coagulation function.