氨溴特罗口服溶液治疗小儿支气管炎的效果观察

Observation on the Effect of Ambroterol Oral Solution in the Treatment of Bronchitis in Children

目的:探讨氨溴特罗口服溶液治疗小儿支气管炎的效果。方法:选取2021年4月—2022年10月铜仁市妇幼保健院收治的支气管炎患儿104例作为研究对象,随机分为对照组与研究组,各52例。对照组给予常规治疗,研究组在对照组基础上给予氨溴特罗口服溶液治疗。比较两组治疗效果。结果:研究组治疗总有效率高于对照组,差异有统计学意义(P=0.027)。研究组止喘时间、止咳时间、气促改善时间、住院时间均短于对照组,差异有统计学意义(P<0.001)。治疗前,两组pH值、动脉血氧分压(PaO_(2))、动脉血氧饱和度(SaO_(2))比较,差异无统计学意义(P>0.05);治疗后,两组pH值、PaO_(2)、SaO_(2)均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05)。治疗前,两组C反应蛋白(CRP)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)水平比较,差异无统计学意义(P>0.05);治疗后,两组CRP、IL-6、IL-8水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05)。结论:氨溴特罗口服溶液治疗小儿支气管炎的效果显著,可促进患儿症状改善,缩短住院时间,改善血气指标,减轻炎性反应。

Objective:To investigate the effect of ambroterol oral solution on pediatric bronchitis.Methods:A total of one hundred and four children with bronchitis admitted to Tongren Maternal and Child Health Hospital from April 2021 to October 2022 were selected as the study objects,and randomly divided into control group and study group,with fifty-two cases in each group.The control group was given conventional treatment,and the study group was given ambroterol oral solution based on the control group.The therapeutic effect of the two groups was compared.Results:The total effective rate of the study group was higher than that of the control group,the difference was statistically significant(P=0.027);The time to stop asthma,cough,shortness of breath improvement and hospital stay in the study group were shorter than those in the control group,and the difference was statistically significant(P<0.001);Before treatment,there was no significant difference in pH value,arterial partial pressure of oxygen(PaO_(2))and arterial oxygen saturation(SaO_(2))between the two groups(P>0.05);After treatment,pH,PaO_(2)and SaO_(2)in both groups were higher than before treatment,and the study group was higher than the control group,the difference was statistically significant(P<0.05);Before treatment,there was no significant difference in C-reactive protein(CRP),interleukin-6(IL-6)and interleukin-8(IL-8)levels between the two groups(P>0.05);After treatment,the levels of CRP,IL-6 and IL-8 in 2 groups were lower than before treatment,and the study group was lower than the control group,with statistical significance(P<0.05).Conclusion:Ambroterol oral solution is effective in the treatment of bronchitis in children,which can promote the improvement of symptoms,shorten the length of hospital stay,improve blood gas index and reduce inflammatory response.