厄贝沙坦联合二甲双胍治疗2型糖尿病合并高血压的临床效果

Therapeutic Effect of Combination of Irbesartan and Metformin in Treating Type 2 Diabetes Mellitus Patients with Hypertension

目的:探讨厄贝沙坦联合二甲双胍治疗2型糖尿病合并高血压的临床效果。方法:选取2021年4月—2023年4月广州市从化区良口镇中心卫生院收治的2型糖尿病合并高血压患者108例作为研究对象,随机分为对照组和观察组,各54例。对照组给予二甲双胍治疗,观察组在对照组基础上给予厄贝沙坦治疗。比较两组治疗效果。结果:治疗前,两组糖化血红蛋白(HbA_(1c))、餐后2 h血糖(2 hPBG)、空腹血糖(FBG)水平比较,差异无统计学意义(P>0.05);治疗后,观察组HbA_(1c)、2 hPBG、FBG水平均低于对照组,差异有统计学意义(P<0.05)。治疗前,两组舒张压、收缩压水平比较,差异无统计学意义(P>0.05);治疗后,观察组收缩压、舒张压水平低于对照组,差异有统计学意义(P<0.05)。治疗前,两组血肌酐(Scr)、尿素氮(BUN)、血尿酸(BUA)水平比较,差异无统计学意义(P>0.05);治疗后,观察组Scr、BUN、BUA水平均低于对照组,差异有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论:厄贝沙坦联合二甲双胍治疗2型糖尿病合并高血压的效果显著,可降低患者血糖、血压水平,保护患者肾功能,且不会增加不良反应。

Objective:to explore the therapeutic effect of Irbesartan combined with metformin in treating type 2 diabetes mellitus patients with hypertension.Methods:108 patients with type 2 diabetes mellitus and hypertension admitted to Liangkou Town Cen⁃tral Health Hospital,Conghua District,Guangzhou from April 2021 to April 2023 were selected as the study subjects,and were randomly divided into the control group and the observation group,with 54 cases each.The control group was administered with metformin and the observation group was given irbesartan treatment on the basis of the control group.The therapeutic effects of the two groups were compared.Results:Before treatment,the levels of glycated hemoglobin(HbA_(1c)),2-hour postprandial blood glu⁃cose(2 hPBG),and fasting blood glucose(FBG)of the two groups were compared with each other,and the differences were not sta⁃tistically significant(P>0.05);after treatment,the levels of HbA_(1c),2 hPBG,and FBG of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).Before treatment,the diastolic and systolic blood pressure levels of the two groups were compared,and the difference was not statistically significant(P>0.05);after treat⁃ment,the systolic and diastolic blood pressure levels of the observation group were lower than those of the control group,and the difference was statistically significant(P<0.05).Before treatment,the levels of blood creatinine(Scr),urea nitrogen(BUN),and blood uric acid(BUA)were compared between the two groups,and the difference was not statistically significant(P>0.05);after treatment,the levels of Scr,BUN,and BUA in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).Comparing the total incidence of adverse reactions between the two groups did not show a sta⁃tistically significant difference(P>0.05).Conclusion:Combination of Irbesartan and metformin is effective in treating type 2 diabe⁃tes mellitus patients with hypertension,which can reduce their blood glucose and blood pressure levels,protect the their renal function,and does not increase the adverse reactions.