依达拉奉右崁醇联合丁苯酞治疗急性脑栓塞的临床效果

Therapeutic Effect of Edaravone dexkanol Combined with Butylphthalide in the treatment of Acute Cerebral Embolism

目的:分析依达拉奉右崁醇联合丁苯酞治疗急性脑栓塞的临床效果。方法:选取2021年1月—2022年12月黔南布依族苗族自治州人民医院收治的60例急性脑栓塞患者作为研究对象,以抽签法分为对照组与观察组,各30例。对照组应用丁苯酞氯化钠注射液治疗,观察组在对照组基础上应用依达拉奉右崁醇注射用浓溶液治疗。比较两组临床效果、不良反应发生情况、血脂指标及凝血功能指标。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P=0.012)。观察组不良反应发生率低于对照组,差异有统计学意义(P<0.001)。治疗前,两组总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)水平比较,差异无统计学意义(P>0.05);治疗后,两组TC、LDL-C水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗前,两组纤维蛋白酶原水平、凝血酶原时间(PT)比较,差异无统计学意义(P>0.05);治疗后,两组纤维蛋白酶原水平均低于治疗前,且观察组低于对照组,两组PT均短于治疗前,且观察组短于对照组,差异有统计学意义(P<0.05)。结论:依达拉奉右崁醇联合丁苯酞治疗急性脑栓塞的效果显著,可降低不良反应发生率,改善患者血脂指标及凝血功能。

Objective:to analyze the clinical effect of edaravone dextran combined with butylphthalide in the treatment of acute cerebral embolism.Methods:60 patients with acute cerebral embolism admitted to the People's Hospital of Qiannan Buyi and Miao Autonomous Prefecture from January 2021 to December 2022 were selected as the study subjects,and were divided into the control group and the observation group,each with 30 cases,by adopting lottery method.The control group was treated with butylphthalide sodium chloride injection,and the observation group was treated with edaravone dextranol injection with concentrated solution on the basis of the control group.The therapeutic effects,occurrence of adverse reactions,lipid indexes and coagulation function indexes of both groups were compared.Results:The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P=0.012).The incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.001).Before treatment,the levels of total cholesterol(TC)and low-density lipoprotein cholesterol(LDL-C)in the two groups were compared,and the difference was not statistically significant(P>0.05);after treatment,the levels of TC and LDL-C in the two groups were lower than before treatment,and the observation group was lower than the control group,and the difference was statistically significant(P<0.05).Before treatment,the level of fibrinogen and prothrombin time(PT)of the two groups were compared,and the difference was not statistically significant(P>0.05);after treatment,the average of fibrinogen water of the two groups was lower than before treatment,and the observation group was lower than the control group,and the PT of the two groups was shorter than before treatment,and the observation group was shorter than the control group,and the difference was statistically significant(P<0.05).Conclusion:Edaravone dexkanol combined with butylphthalide is effective in treating patients with acute cerebral embolism,which can reduce the incidence of adverse reactions and improve their lipid index and coagulation function.