无创通气治疗脓毒症合并急性呼吸窘迫综合征的临床效果

Therapeutic Effect of Non-invasive Ventilation in the treatment of Sepsis Combined with Acute Respiratory Distress Syndrome

目的:探讨无创通气(NIV)治疗脓毒症合并急性呼吸窘迫综合征(ARDS)的效果。方法:选取2022年1月—2023年2月廊坊市人民医院收治的102例脓毒症合并ARDS患者作为研究对象,采用随机数字表法分为观察组和对照组,各51例。对照组采用经头罩供氧,观察组采取NIV治疗。比较两组治疗效果、肺功能指标、炎性因子水平、并发症发生情况。结果:观察组总有效率高于对照组,差异有统计学意义(P=0.021)。治疗前,两组第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、最大通气量(MVV)水平比较,差异无统计学意义(P>0.05);治疗后,两组FEV1、FVC、MVV高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。治疗前,两组血清白细胞介素-6(IL-6)、C反应蛋白(CRP)水平比较,差异无统计学意义(P>0.05);治疗后,两组血清IL-6、CRP水平低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组并发症发生率低于对照组,差异有统计学意义(P=0.025)。结论:NIV治疗脓毒症合并ARDS的效果显著,有助于提高患者肺功能,降低炎性因子水平及并发症发生率。

Objective:To investigate the effect of non-invasive ventilation(NIV)in the treatment of sepsis combined with acute respiratory distress syndrome(ARDS).Methods:102 patients with sepsis combined with ARDS admitted to Langfang People's Hospital from January 2022 to February 2023 were selected as the study subjects,and were divided into the observation group and the control group using the randomized numerical table method,with 51 cases in each group.The control group was treated with simple face mask oxygen supply,and the observation group was treated with NIV.The therapeutic effect,lung function index,inflammatory factor level,and complication occurrence were compared in both groups.Results:The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P=0.021).Before treatment,the levels of forced expiratory volume in 1 second(FEV1),forced vital capacity(FVC),and maximum ventilation volume(MVV)of the two groups were compared,and the difference was not statistically significant(P>0.05).After treatment,FEV1,FVC,and MVV of the two groups were higher than those before treatment,and the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Before treatment,the serum interleukin-6(IL-6)and C-reactive protein(CRP)levels of the two groups were compared,and the difference was not statistically significant(P>0.05).After treatment,the serum IL-6 and CRP levels of the two groups were lower than those before treatment,and the observation group was lower than the control group,and the difference was statistically significant(P<0.05).The complication rate of the observation group was lower than that of the control group,and the difference was statistically significant(P=0.025).Conclusion:NIV is effective in treating sepsis combined with ARDS,which helps to improve their lung function and reduce the level of inflammatory factors and complication rate.