地塞米松治疗小儿支原体感染致大叶性肺炎的临床疗效观察

Clinical Efficacy of Dexamethasone in the Treatment of Pediatric Mycoplasma Infection Causing Lobar Pneumonia in Children

目的:分析小儿支原体感染致大叶性肺炎采用地塞米松治疗的临床疗效。方法:选取2020年1月—2022年12月菏泽医学专科学校附属医院收治的支原体感染致大叶性肺炎患儿800例,根据随机数字表法分为参照组与研究组,各400例。参照组采用常规治疗方式,研究组采用常规治疗联合地塞米松治疗。比较两组患儿临床效果。结果:研究组治疗总有效率高于参照组,差异有统计学意义(P<0.001);研究组发热、咳嗽、胸痛、呼吸窘迫、肺部啰音消失时间短于参照组,差异有统计学意义(P<0.001);用药7 d后,两组降钙素原、乳酸脱氢酶、超敏C反应蛋白水平均降低,研究组低于参照组,差异有统计学意义(P<0.05);用药7 d后,两组第1秒用力呼气容积(FEV_(1))、用力肺活量(FVC)、FEV_(1)/FVC、呼吸峰流速水平均升高,研究组高于参照组,差异有统计学意义(P<0.05)。结论:地塞米松治疗小儿支原体感染致大叶性肺炎的疗效较佳,能缩短患儿病程,改善患儿肺功能,降低炎性因子水平,安全性较高。

Objective:To analyze the clinical efficacy of pediatric mycoplasma infection causing lobar pneumonia treated with dexamethasone.Methods:Eight hundred cases of children with mycoplasma infection causing lobar pneumonia admitted to the Affiliated Hospital of Heze Medical College from January 2020 to December 2022 were selected and divided into the reference group and the study group according to the method of randomized numerical table,each of which consisted of four hundred cases.The reference group was treated with conventional treatment,and the study group was treated with conventional treatment combined with dexamethasone.The clinical effects of the two groups were compared.Results:The total effective rate of treatment in the study group was higher than that in the reference group,and the difference was statistically significant(P<0.001);Fever,cough,chest pain,respiratory distress,and disappearance of lung rales were shorter in the study group than in the reference group,and the difference was statistically significant(P<0.001);After 7 d of drug administration,the levels of procalcitonin,lactate dehydrogenase,and ultrasensitive C-reactive protein were reduced in both groups,and the study group was lower than the reference group,with a statistically significant difference(P<0.05);After 7 d of medication,the levels of exertional expiratory volume in the first second(FEV_(1)),exertional lung capacity(FVC),FEV_(1)/FVC,and peak respiratory flow rate increased in both groups,and the study group was higher than the reference group,with a statistically significant difference(P<0.05).Conclusion:Dexamethasone has better efficacy in the treatment of pediatric mycoplasma infections causing lobar pneumonia,which can shorten the duration of the disease,improve the lung function of children,reduce the level of inflammatory factors,and have a high degree of safety.