肝动脉化疗联合介入栓塞术治疗原发性肝癌的临床效果

Clinical Effect of Hepatic Arterial Chemotherapy Combined with Interventional Embolization in the Treatment of Primary Liver Cancer

目的:探讨肝动脉化疗联合介入栓塞术治疗原发性肝癌(PLC)的临床效果。方法:选取2020年1月—2023年1月宿迁第一人民医院收治的PLC患者80例为观察对象,根据随机数字表法分为对照组与研究组,各40例。对照组行肝动脉化疗,研究组行肝动脉化疗联合介入栓塞术。比较两组临床疗效、血清肿瘤标志物水平[甲胎蛋白(AFP)、癌胚抗原(CEA)]、肝功能指标[天门冬氨酸氨基转移酶(AST)、总胆红素(TBiL)、丙氨酸氨基转移酶(ALT)]及不良反应发生率。结果:研究组治疗总有效率高于对照组,差异有统计学意义(P=0.044);治疗后,两组患者AFP、CEA水平均降低,研究组低于对照组,差异有统计学意义(P<0.05);治疗后,两组AST、TBiL、ALT水平均升高,但研究组低于对照组,差异有统计学意义(P<0.05);研究组不良反应发生率低于对照组,差异有统计学意义(P=0.025)。结论:PLC患者采用肝动脉化疗联合介入栓塞术治疗效果较好,可降低肿瘤标志物水平,且对肝功能损伤小,安全性高。

Objective:To investigate the clinical effect of hepatic arterial chemotherapy combined with interventional embolization in the treatment of primary liver cancer(PLC).Methods:Eighty PLC patients admitted to Suqian First People's Hospital from January 2020 to January 2023 were selected as the observation objects,and were divided into control group and study group according to random number table method,with forty cases in each group.The control group received hepatic arterial chemotherapy,and the study group received hepatic arterial chemotherapy combined with interventional embolization.The clinical efficacy,serum tumor marker levels[alpha-fetoprotein(AFP),carcinoembryonic antigen(CEA)],liver function indexes[aspartate aminotransferase(AST),total bilirubin(TBiL),alanine aminotransferase(ALT)]and incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was higher than that of the control group,the difference was statistically significant(P=0.044);After treatment,AFP and CEA levels were decreased in both groups,and the study group was lower than the control group,the difference was statistically significant(P<0.05);After treatment,AST,TBiL and ALT levels were increased in both groups,but the study group was lower than the control group,the difference was statistically significant(P<0.05);The incidence of adverse reactions in study group was lower than that in control group,and the difference was statistically significant(P=0.025).Conclusion:In PLC patients,hepatic arterial chemotherapy combined with interventional embolization has a good effect,can reduce the level of tumor markers,and has little damage to liver function and high safety.