三联疗法联合益生菌治疗小儿慢性胃炎合并幽门螺杆菌感染的效果分析

Effect of Triple Therapy Combined with Probiotics on Chronic Gastritis Complicated with Helicobacter Pylori Infection in Children

目的:观察小儿慢性胃炎合并幽门螺杆菌(Hp)感染应用三联疗法联合益生菌治疗的临床效果。方法:选取2021年9月—2022年9月深圳市坪山区人民医院收治的慢性胃炎合并Hp感染患儿110例为观察对象,根据随机数字表法分为对照组与观察组,各55例。对照组采用三联疗法治疗,观察组在对照组基础上联合益生菌治疗。比较两组治疗效果、Hp根除率、炎性因子水平、肠道菌群水平、不良反应发生率。结果:观察组治疗效果总有效率高于对照组,差异有统计学意义(P=0.008);观察组Hp根除率高于对照组,差异有统计学意义(P=0.003);治疗后,观察组白细胞介素-6、白细胞介素-8、肿瘤坏死因子-α水平低于对照组,差异有统计学意义(P<0.001);治疗后,观察组肠杆菌、肠球菌水平低于对照组,乳酸杆菌、双歧杆菌、双歧杆菌值/肠杆菌值水平高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:慢性胃炎合并Hp感染患儿采用三联疗法联合益生菌治疗效果显著,可提高Hp根除率,改善患儿炎性因子水平及肠道菌群情况,安全性较高。

Objective:To observe the clinical effect of triple therapy combined with probiotics on chronic gastritis complicated with Helicobacter pylori(Hp)infection in children.Methods:A total of one hundred and ten children with chronic gastritis complicated with Hp infection treated in Shenzhen Pingshan District People's Hospital from September 2021 to September 2022 were selected as the observation objects,and were divided into control group and observation group according to random number table method,with fifty-five cases in each group.The control group was treated with triple therapy,and the observation group was treated with probiotics based on the control group.The therapeutic effect,Hp eradication rate,inflammatory factor level,intestinal flora level and incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P=0.008);The eradication rate of Hp in observation group was higher than that in control group,and the difference was statistically significant(P=0.003);After treatment,the levels of interleukin-6,interleukin-8 and tumor necrosis factor-αin observation group were lower than those in control group,the difference was statistically significant(P<0.001);After treatment,the levels of enterobacterium and enterococcus in observation group were lower than those in control group,while the levels of lactobacillus,bifidobacterium and bifidobacterium value/enterobacterium value in observation group were higher than those in control group,with statistical significance(P<0.05);There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The effect of triple therapy combined with probiotics on children with chronic gastritis combined with Hp infection is significant,which can increase the eradication rate of Hp,improve the level of inflammatory factors and intestinal flora of children,with high safety.