左氧氟沙星联合卷曲霉素对耐多药肺结核患者的影响

Effect of Levofloxacin Combined with Capreomycin in Patients with Multidrug-resistant Tuberculosis

目的:探讨左氧氟沙星联合卷曲霉素对耐多药肺结核患者的影响。方法:选取2020年1月—2022年6月普宁市人民医院感染科收治的耐多药肺结核患者110例为研究对象,按照随机性、数字化分组原则分为对照组、联合组,各55例。对照组采用链霉素、乙胺丁醇、利福喷汀、杨酸钠常规药物治疗,联合组采用左氧氟沙星联合卷曲霉素、乙胺丁醇、利福喷汀、杨酸钠治疗。比较两组临床疗效、血清炎性因子、不良反应发生情况。结果:联合组临床疗效总有效率高于对照组,差异有统计学意义(P=0.030);治疗后,两组白细胞介素-17、肿瘤坏死因子-α水平降低,联合组低于对照组,差异有统计学意义(P<0.05);联合组不良反应发生率低于对照组,差异有统计学意义(P=0.014)。结论:左氧氟沙星与卷曲霉素联合治疗方案在耐多药肺结核患者中应用价值较高,有助于减轻患者的临床症状,改善炎性因子水平,安全性高。

Objective:To investigate the effect of levofloxacin combined with capreomycin on patients with multidrug-resistant tuberculosis.Methods:One hundred and ten patients with multidrug-resistant tuberculosis admitted to the Department of Infection of Puning People's Hospital from January 2020 to June 2022 were selected as the study subjects,and they were divided into the control group and the combined group,each with fifty-five cases,in accordance with the principle of randomization and digitized grouping.The control group was treated with conventional drugs of streptomycin,ethambutol,rifapentine and sodium salicylate,and the combined group was treated with levofloxacin combined with capreomycin,ethambutol,rifapentine and sodium salicylate.The clinical efficacy,serum inflammatory factor and occurrence of adverse reactions were compared between the two groups.Results:The total effective rate of clinical efficacy of the combined group was higher than that of the control group,and the difference was statistically significant(P=0.030);after treatment,the levels of interleukin-17 and tumor necrosis factor-αwere reduced in both groups,and the combined group was lower than the control group,and the difference was statistically significant(P<0.05);the incidence of adverse reactions in the combined group was lower than that in the control group,and the difference was statistically significant(P=0.014).Conclusion:The combined therapeutic regimen of levofloxacin and capreomycin has high application value in patients with multidrug-resistant tuberculosis,which helps to reduce the clinical symptoms of the patients,improve the level of inflammatory factors,and has a high degree of safety.