丙戊酸钠联合喹硫平治疗双相情感障碍躁狂发作的效果观察

Therapeutic Effect of Sodium Valproate combined with Quetiapine in the treatment of Manic Episodes of Bipolar Affective Disorder

目的:探讨丙戊酸钠联合喹硫平治疗双相情感障碍躁狂发作的效果。方法:选取2021年1月—2023年1月北京市西城区平安医院收治的80例双相情感障碍躁狂发作患者作为研究对象,根据随机数字法分为观察组与对照组,各40例。对照组应用喹硫平治疗,观察组在对照组基础上应用丙戊酸钠治疗,比较两组临床症状、血清学指标、治疗效果、不良反应发生情况。结果:治疗前,两组汉密尔顿抑郁量表(HAMD)和贝克拉范森躁狂量表(BRMS)评分比较,差异无统计学意义(P>0.05);治疗后,两组HAMD、BRMS评分低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗前,两组血清脑源性神经营养因子(BDNF)、白细胞介素-4(IL-4)、白细胞介素-10(IL-10)水平比较,差异无统计学意义(P>0.05);治疗后,两组BDNF、IL-4、IL-10水平高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。观察组治疗有效率高于对照组,差异有统计学意义(P=0.013)。治疗期间两组均未出现不良反应。结论:丙戊酸钠联合喹硫平治疗双相情感障碍躁狂发作的效果显著,能够抑制患者抑郁及躁狂症状,改善血清学指标,并且不会增加不良反应。

Objective:To explore the therapeutic effect of sodium valproate combined with quetiapine in treating manic episodes of bipolar disorder.Methods:80 cases of bipolar disorder manic episodes patients admitted to Beijing Xicheng District Ping'an Hospital from January 2021 to January 2023 were selected as study subjects,and were divided into observation group and control group according to the random number method,40 cases each.The control group was treated with quetiapine,and the observation group was treated with sodium valproate on the basis of the control group,and then the clinical symptoms,serologic indexes,therapeutic effects,and the occurrence of adverse reactions were compared in the two groups.Results:Before treatment,the scores of Hamilton Depression Scale(HAMD)and Beck Laffanson Mania Scale(BRMS)of the two groups were compared,the difference was not statistically significant(P>0.05);after treatment,the scores of HAMD and BRMS of the two groups were lower than that before treatment,and the observation group was lower than those of the control group,the difference was statistically significant(P<0.05).Before treatment,the serum brain-derived neurotrophic factor(BDNF),interleukin-4(IL-4),interleukin-10(IL-10)levels of the two groups were compared,and the difference was not statistically significant(P>0.05);after treatment,the levels of BDNF,IL-4,IL-10 of the two groups were higher than those before treatment,and the observation group was higher than those of the control group,and the difference was statistically significant(P<0.05).The therapeutic efficiency of the observation group was higher than that of the control group,and the difference was statistically significant(P=0.013).No adverse reactions occurred in both groups during the treatment period.Conclusion:Sodium valproate combined with quetiapine is effective in treating manic episodes of bipolar disorder,which can inhibit patients'depressive and manic symptoms,improve their serologic indexes,and will not increase adverse reactions.