阻塞性睡眠呼吸暂停与勃起功能障碍发病风险的Meta分析

Meta⁃analysis of obstructive sleep apnea and the risk of developing erectile dysfunction

目的 系统评价阻塞性睡眠呼吸暂停(obstructive sleep apnea, OSA)与勃起功能障碍(Erectile dysfunction, ED)的发病风险关系。方法 计算机检索Scopus、Cochrane Library、PubMed、Ovid MEDLINE、万方数据库、中国知网,搜集阻塞性睡眠呼吸暂停与勃起功能障碍发生关系的相关研究,检索时间为建库起至2023年2月19日。由2名研究人员完成文献筛选、资料提取、评价纳入研究的偏倚风险后进行Meta分析。结果 纳入19篇文章,共116 419病例。Meta分析结果显示:患阻塞性睡眠呼吸暂停人群勃起功能障碍发病风险是非阻塞性睡眠呼吸暂停人群的2.52倍,差异具有统计学意义[相对比值比(odds ratio,OR)=2.52,95%可信区间(Confidence interval,CI)(1.69,3.75),P值(P value)<0.001]。亚组分析发现地域为欧洲,样本数量<400,OSA评价工具非多导睡眠图,样本来源为数据库的亚组的OSA和ED具有显著相关性。结论 阻塞性睡眠呼吸暂停可能是勃起功能障碍的危险因素。

Objective To comprehensively assess the correlation between obstructive sleep apnea(OSA)and the incidence of erectile dysfunction(ED).Method The pertinent literature regarding the association between OSA and ED was systematically retrieved from databases including Scopus,Cochrane Library,PubMed,Ovid MEDLINE,Wanfang,and CNKI.The search timeframe encompassed the period from database inception up until December 19,2022.Following thorough literature screening,data extraction,and bias risk evaluation conducted by two researchers,a meta⁃analysis was conducted.Results A total of nineteen articles comprising 116419 cases were included in the analysis.The results of the meta⁃analysis demonstrated a statistically significant association between OSA and an increased risk of ED,with individuals suffering from OSA being 2.52 times more likely to develop ED compared to those without OSA[OR=2.52,95%CI(1.69,3.75),P<0.001].Notably,Subgroup analysis indicated a significant association between OSA and ED in the European,small sample size,non⁃polysomnographic OSA evaluation tool,and database origin subgroups.