体外受精-胚胎移植中第3天极低等级胚胎4例成功活产病例报道并文献复习

Four cases of successful live birth after transferred with extremely low-grade cleavage-stage embryos on day 3 of IVF-ET and literature review

目的探讨体外受精-胚胎移植中取卵后移植第3天极低等级胚胎的临床价值。方法回顾性分析4例取卵后第3天胚胎质量极差且新鲜移植后均成功活产的临床案例, 并进行相关文献复习。结果 4例移植极低等级胚胎12 d后血人绒毛膜促性腺激素值显示成功生化妊娠, 5周后B超提示均为宫内单胎妊娠, 最终4名孕妇均成功活产, 3例患者足月产, 1例患者早产, 胎儿出生后健康状况良好。结论通过对4例移植第3天极低等级胚胎成功活产的分析, 建议为少数周期第3天所有胚胎质量极差的患者提供新的尝试与选择。

ObjectiveTo explore the possible of clinical application value after transferred with day 3 extremely low-grade cleavage-stage embryos during in vitro fertilization and embryo transfer.MethodsThe clinical outcomes of four cases with extremely low-grade cleavage-stage embryos on day 3 undergoing IVF-ET were retrospectively analyzed and the related literatures were reviewed.ResultsFour cases successfully got pregnant after 12 days of transplantation of extremely low-grade embryos detected by human chorionic gonadotropin testing, and all of them were intrauterine singleton pregnancies. Finally these four patients had successful live births, and three of them were full-term delivery, one of them was delivery prematurely. All the babies were in the good health.ConclusionThere is still a degree of successful pregnancy and live birth rate after transferred with day 3 extremely low-grade cleavage-stage embryos. If the quality of all the embryos was extremely low-grade on day 3, we can provide new attempts and choices for the patients who were often giving up embryos transfer.