铁死亡与女性生殖相关疾病的研究进展

Research progress of ferroptosis and female reproductive-related diseases

铁及铁代谢参与调节女性生殖系统的生理功能。必要的铁对女性生殖功能起着积极作用, 而铁过载可诱导机体代谢过程发生异常。铁死亡是一种铁依赖性的脂质氧化物代谢障碍, 伴随着抗氧化机制失衡及脂质活性氧堆积的细胞死亡方式。研究表明, 子宫内膜异位症、多囊卵巢综合征及滋养细胞功能障碍疾病的病理过程中都有着不同程度的铁死亡, 并且铁死亡通路及相关基因参与早期胚胎发育、胎盘氧化应激, 卵母细胞功能调控等, 提示铁代谢及铁死亡关键基因作为潜在治疗靶点的可能性。目前, 铁死亡女性生殖系统功能及相关疾病的研究仍不明确, 本文就铁死亡及相关机制在女性生殖系统相关疾病中的研究进展进行讨论, 以期为临床相关疾病的诊疗提供参考。

Iron and iron metabolism are involved in regulating the physiological functions of the female reproductive system.Essential iron plays a positive role in female development and reproductive function,while iron overload can induce abnormal metabolic processes in the body.Ferroptosis is a cellular iron-dependent disorder of lipid oxide metabolism,accompanied by oxidative imbalance and accumulation of lipid reactive oxygen species.Studies have shown that ferroptosis occurred in the pathology of endometriosis,polycystic ovary syndrome and trophoblast dysfunction diseases.Besides,the pathways and related genes of ferroptosis are involved in early embryonic development,placental oxidative stress,and regulation of oocyte function,suggesting the possibility of key molecules of iron metabolism and ferroptosis as potential therapeutic targets.The regulation mechanism for ferroptosis in female reproduction-related diseases is unclear now.This review discussed and summarized the recent research progress of iron overload and ferroptosis in female reproductive system and related diseases,in order to provide reference for clinical treatment of related diseases.