天麻钩藤饮及其单味药治疗帕金森病的研究进展

Tianma Goutengyin and Its Single Herb in Treatment of Parkinson's Disease: A Review

帕金森病(PD)属于慢性进展性神经系统退行性疾病的一种,近年来具有较高患病率,尤以在中老年人群中高发。PD在中医学上属于“颤病”“震颤”等范畴,天麻钩藤饮是出自《中医内科杂病证治新义》的经典名方。该文探讨了天麻钩藤饮治疗PD的理论基础,并基于网络药理学,总结了天麻钩藤饮及其单味药治疗PD的相关研究,对天麻钩藤饮及其单味药治疗PD的临床应用及作用机制进行了论述。综述发现,天麻钩藤饮治疗PD的作用机制可能与抗氧化应激、抑制炎症反应、调节神经递质水平和保护多巴胺(DA)能神经元等相关。而天麻钩藤饮中单味药治疗PD的主要成分有天麻素、钩藤碱、京尼平苷、栀子醇、杜仲醇苷、益母草碱、黄芩素、茯苓聚糖、牛膝甾酮等,可通过抗炎、抗氧化应激、影响钙离子浓度、恢复线粒体功能及保护DA能神经元等机制改善PD患者的相关症状。该文综述天麻钩藤饮及其单味药治疗PD的研究进展,以期为天麻钩藤饮治疗PD的遣方用药及后续研究天麻钩藤饮及其单味药治疗PD的作用机制提供参考依据,发挥中医药治疗PD的优势。

Parkinson's disease(PD)is a kind of chronic progressive neurodegenerative disease that has a high prevalence rate in recent years,especially in the elderly.PD belongs to the category of"tremor disease"and"tremor"in traditional Chinese medicine,and Tianma Goutengyin is a classic prescription contained in the Synopsis of The New Significance of Patterns and Treatment in Miscellaneous Diseases(《中医内科杂病证治新义》).This article explored the theory of Tianma Goutengyin in the treatment of PD,and based on network pharmacological research,the article summarized relevant research on Tianma Goutengyin and its single herb in the treatment of PD.Moreover,it discussed the clinical applications and mechanisms of Tianma Goutengyin and its single herb in the treatment of PD.It is found that the mechanisms of Tianma Goutengyin in treating PD may be related to resisting oxidative stress,inhibiting inflammatory response,regulating neurotransmitters,and protecting dopamine(DA)neurons.Besides,the main components of the single herb in Tianma Goutengyin for treating PD are gastrodin,rhynchophylline,geniposide,gardenial alcohol,eucommitol glycoside,motherwort alkaloid,baicalin,pachyman,and achyranthes bidentata sterol.They can improve the related symptoms of PD patients by inhibiting inflammatory response,resisting oxidative stress,affecting calcium ion concentration,restoring mitochondrial function,and and protecting DA neurons.This article summarized the research progress of Tianma Goutengyin and its single herb in treating PD, so as to provide a reference for the prescription andmedication of Tianma Goutengyin in the treatment of PD and subsequent research on the mechanisms of TianmaGoutengyin and its single herb in the treatment of PD and give play to the advantages of traditional Chinesemedicine in the treatment of PD.