冠状动脉慢性完全闭塞病变侧支研究进展

Researeh Advances of Collaterals in Chronic Total Occlusions of Coronary Arteries

在冠状动脉慢性完全闭塞(CTO)病变中,侧支的形成是特征性的表现。侧支维持着病变远端的心肌活力,对于后续的血运重建十分重要。了解侧支的病理学与病理生理学过程,有助于理解侧支的形态学与功能学评价方法,从而及时地对CTO病变进行诊断和治疗。本文拟综述CTO病变中侧支形成的病理生理学机制以及形态和功能的评估方法,论述侧支的临床意义。

The formation of collaterals is a characteristic feature in the pathogenesis of chronic total occlusion of the coronary arteries.Myocardial viability distal to the lesion maintained by collaterals is critical in facilitating subsequent myocardial revascularization.Comprehensive research on the pathological and pathophysiological processes of the collaterals will help to understand the morphological and functional evaluation methods of the collaterals,which will lead to the timely diagnosis and effective treatment of chronic total occlusion.In this article,we intend to review research advances on collaterals in chronic total occlusion,focusing on the pathophysiological mechanisms,the methods of morphological and functional evaluation,as well as the clinical implication.