地中海饮食模式和心房颤动的发生风险

Alternate Mediterranean diet score and risk of atrial fibrillation

目的:探讨地中海饮食模式与心房颤动之间的相关性。方法:本研究为单中心,病例对照研究。收集2018年至2021年,在北京安贞医院就诊的873例患者,首次发生心房颤动患者436例,匹配对照组437例。根据饮食频率调查问卷(food frequency questionnaires,FFQ)计算出改良地中海饮食评分(alternate Mediterranean diet,AMED),改良地中海饮食评分可以评价非地中海人群对地中海饮食模式的依从性,其得分为0~9分。分析AMED与心房颤动的相关性。结果:研究参与者的平均年龄(58.2±1.3)岁,男性596例(68.3%)。经多因素回归分析后发现,AMED,高血压病史以及BMI与首发心房颤动相关(OR=0.72,95%CI:0.50~0.95,P <0.001;OR=1.75,95%CI:1.26~2.45,P <0.001;OR=1.53,95%CI:1.05~2.16,P=0.006)。分析AMED中每种食物与心房颤动的相关性,发现水果类食物,蔬菜类食物减少心房颤动发生风险,饮酒增加心房颤动发生风险(OR=0.74,95%CI:0.57~0.97,P=0.028;OR=0.53,95%CI:0.41~0.70,P <0.001;OR=2.0195%CI:1.52~2.63,P<0.001)。与AMED<4分的人群相比较,AMED≥6分的人群新发心房颤动的风险明显减少(OR=0.69,95%CI:0.47~0.96,P=0.030)。结论:AMED和首发心房颤动成负相关,地中海饮食模式依从性好的人群较依从性差的人群,心房颤动发生风险明显减少。

Objective:The aim of this study was to assess the association between adherence to Mediterranean diet pattern and incidence of the presence atrial fibrillation(AF).Methods:This is a single center,Case-control study.We included 873 subjects,436 AF patients and 436 controls matched per age and sex from 2018-2021.Adherence to an alternate Mediterranean diet score(AMED)which scored as 0-9 was computed from food frequency questionnaires(FFQ).The association of the AMED with the incidence of AF was evaluated through multiple logistic regression models.Results:The average age of the study participants was(58.2±1.3)years,men were 596(68.3%).After multivariate adjustment,we found associations between AMED,hypertension history,BMI and the presence of AF(OR=0.72,95%CI:0.50-0.95,P<0.001,OR=1.75,95%CI:01.26-2.45,P<0.001,OR=1.53,95%CI:01.05-2.16,P=0.006).After analyze every component of AMED,we found associations between fruits,vegetables,drink and the presence of AF (OR=0.74, 95%CI:00.57-0.97, P=0.028, OR=0.53, 95%CI:00.41-0.70, P < 0.001, OR=2.01, 95%CI:01.52-2.63, P< 0.001) . As compared with AMED<4 the OR of AF for AMED ≥ 6 was 0.69 (95%CI:00.47-0.96, P =0.030) .Conclusions: Adherence to Mediterranean diet pattern is inversely associated with the risk of AF in this Northern Chinese population.