脂毒性在肌少症发生发展中作用的研究进展

Progress of research on role of lipotoxicity in pathogenesis of sarcopenia

肌肉减少症(肌少症)是老年人不可忽视的健康问题。肥胖老年人肌少症的发生可能与游离脂肪酸、甘油二酯、神经酰胺等脂毒性物质在细胞内蓄积对骨骼肌细胞造成的脂毒性息息相关。脂毒性物质通过诱导骨骼肌细胞炎性反应、氧化应激、内质网应激、胰岛素抵抗,导致骨骼肌细胞蛋白质代谢紊乱和再生障碍,最终导致肌少症的发生。目前,骨骼肌脂毒性导致肌少症发生发展的机制并不完全明确,进一步的深入研究可能给肌少症的预防和诊治带来新的方向。

Sarcopenia is a serious health concern that must be payed attention by aged people.The occurrence of sarcopenia in obese older individuals may be intricately linked to lipotoxic substances such as free fatty acids(FFA),diacylglycerols(DAG),and ceramides,which are toxic to skeletal muscle cells.Lipotoxic substances induce inflammatory responses,oxidative stress,endoplasmic reticulum stress,and insulin resistance in skeletal muscle cells,disrupting protein metabolism and impairing regeneration and then lead to the onset of sarcopenia.Up to the present,the precise mechanisms by which lipotoxicity in skeletal muscle results in the development of sarcopenia remain incompletely understood.Further research may highlight the orientation for the prevention and treatment of sarcopenia.