宫颈癌组织中DEK与MMP-7、N-cadherin的表达及临床意义

The Expression and Clinical Significance of DEK,MMP-7 and N-cadherin in Cervical Carcinoma

目的观察宫颈癌组织中DEK与MMP-7、N-cadherin的表达情况,并探讨其在宫颈癌的临床意义。方法收集2016年1月-2021年12月在潍坊市中医院手术切除,并经病理确诊为宫颈鳞状细胞癌组织80例,选取癌旁正常宫颈组织标本50例,采用免疫组化法检测两组中DEK与MMP-7、N-caherin蛋白的表达情况,分析三者与宫颈癌临床病理特征的关系,并进一步分析三种蛋白在宫颈癌中表达的相关性。结果DEK、MMP-7、N-cadherin在宫颈癌组织中的表达高于癌旁正常宫颈组织(P<0.05);DEK与MMP-7、N-caherin的高表达与宫颈癌分化程度、淋巴结转移及TNM分期相关(P<0.05),与宫颈癌患者年龄、肿瘤大小均无关(P>0.05)。宫颈癌中DEK的表达分别与MMP-7(r=0.269,P=0.008)、N-caherin(r=0.295,P=0.004)的表达呈正相关。结论DEK与宫颈癌的发生有关,且与宫颈癌的组织分化及浸润转移有关,其在宫颈癌中的作用机制可能与MMP-7、N-caherin有关。

Objective To observe the expression of DEK,MMP-7 and N-cadherin in cervical carcinoma,and to explore their clinical significance.Methods From January 2016 to December 2021,80 cases of cervical squamous cell carcinoma tissues and 50 cases of adjacent normal cervical tissues were collected from Weifang Hospital of Traditional Chinese Medicine.The expression of DEK,MMP-7 and N-caherin proteins in the two groups was detected by immunohistochemistry.The relationship between the three proteins and the clinicopathological characteristics of cervical cancer was analyzed,and the correlation between the expression of the three proteins in cervical cancer was further analyzed.Results The expression of DEK,MMP-7 and N-cadherin in cervical cancer tissues was higher than that in adjacent normal cervical tissues(P<0.05).The high expression of DEK,MMP-7 and N-caherin was related to the degree of differentiation,lymph node metastasis and TNM stage of cervical cancer(P<0.05),but not to the age and tumor size of cervical cancer patients(P>0.05).The expression of DEK in cervical cancer was positively correlated with the expression of MMP-7(r=0.269,P=0.008)and N-caherin(r=0.295,P=0.004).Conclusion DEK is related to the occurrence of cervical cancer,and is related to the tissue differentiation,invasion and metastasis of cervical cancer.Its mechanism of action in cervical cancer may be related to MMP-7 and N-caherin.