血清IL-6、干扰素-γ、表皮生长因子在鼻咽癌患者中的表达及意义

Expression and Significance of Serum IL-6,Interferon-γand Epidermal Growth Factor in Patients with Nasopharyngeal Carcinoma

目的研究血清白细胞介素-6(IL-6)、干扰素-γ、表皮生长因子在鼻咽癌患者中的表达及价值。方法选取2019年3月-2022年3月在我院诊治的60例鼻咽癌患者为研究对象,并选取同期在我院体检的健康者60名作为对照组,两组均进行血清IL-6、干扰素-γ、表皮生长因子检测。比较两组血清IL-6、干扰素-γ、表皮生长因子水平;分析鼻咽癌不同分期、不同放疗情况及不同预后患者上述指标差异;分析不同血清指标对鼻咽癌患者预后的预测价值。结果鼻咽癌患者血清IL-6、干扰素-γ水平低于对照组,表皮生长因子均高于对照组(P<0.05);Ⅰ、Ⅱ、Ⅲ、Ⅳ期患者表皮生长因子水平呈上升趋势,血清IL-6、干扰素-γ水平呈下降趋势(P<0.05);放疗耐受患者血清IL-6、干扰素-γ水平低于放疗敏感患者,表皮生长因子高于放疗敏感患者(P<0.05);死亡患者血清IL-6、干扰素-γ水平低于存活患者,表皮生长因子水平高于存活患者(P<0.05);血清IL-6+干扰素-γ+表皮生长因子联合检测预测鼻咽癌患者预后的敏感度、特异度均高于各指标单独检测(P<0.05)。结论鼻咽癌患者血清IL-6、干扰素-γ、表皮生长因子存在一定的特点,临床可通过检测各指标水平对鼻咽癌不同分期、不同放疗情况以及不同预后患者进行评估,尤其是血清IL-6、干扰素-γ、表皮生长因子三者联合检测可提高对鼻咽癌患者预后的预测价值,为临床制订治疗方案提供参考。

Objective To study the expression and value of serum interleukin-6(IL-6),interferon-γand epidermal growth factor in patients with nasopharyngeal carcinoma.Methods Sixty patients with nasopharyngeal carcinoma diagnosed and treated in our hospital from March 2019 to March 2022 were selected as the research objects,and 60 healthy people who underwent physical examination in our hospital during the same period were selected as the control group.Serum IL-6,interferon-γand epidermal growth factor were detected in both groups.The levels of serum IL-6,interferon-γand epidermal growth factor were compared between the two groups.The differences of the above indexes in patients with different stages of nasopharyngeal carcinoma,different radiotherapy conditions and different prognosis were analyzed.The predictive value of different serum indicators for the prognosis of patients with nasopharyngeal carcinoma was analyzed.Results The levels of serum IL-6 and interferon-γin patients with nasopharyngeal carcinoma were lower than those in the control group,and the epidermal growth factor was higher than that in the control group(P<0.05).The levels of epidermal growth factor in patients with stage I,II,III and IV showed an upward trend,while the levels of serum IL-6 and interferon-γshowed a downward trend(P<0.05).The levels of serum IL-6 and interferon-γin patients with radiotherapy tolerance were lower than those in patients with radiotherapy sensitivity,and epidermal growth factor was higher than that in patients with radiotherapy sensitivity(P<0.05).The levels of serum IL-6 and interferon-γin the dead patients were lower than those in the survival patients,and the level of epidermal growth factor was higher than that in the survival patients(P<0.05).The sensitivity and specificity of combined detection of serum IL-6+interferon-γ+epidermal growth factor in predicting the prognosis of patients with nasopharyngeal carcinoma were higher than those of single detection of each index(P<0.05).Conclusion There are certain characteristics of serum IL-6,interferon-γand epidermal growth factor in patients with nasopharyngeal carcinoma.Clinically,patients with different stages,different radiotherapy conditions and different prognosis of nasopharyngeal carcinoma can be evaluated by detecting the levels of each index.In particular,the combined detection of serum IL-6,interferon-γand epidermal growth factor can improve the predictive value of the prognosis of patients with nasopharyngeal carcinoma,and provide reference for clinical treatment.