加味二陈汤联合化疗治疗非小细胞肺癌的效果观察

Effect Observation of Jiawei Erchen Decoction Combined with Chemotherapyin the Treatment of Non-small Cell Lung Cancer

目的研究加味二陈汤联合化疗治疗非小细胞肺癌(NSCLC)患者的临床效果。方法选取2019年3月-2022年3月余干县人民医院肿瘤科收治的62例NSCLC患者,按照随机数字表法分为对照组(31例)与观察组(31例)。对照组行化疗治疗,观察组在其基础上联合加味二陈汤治疗。比较两组近期疗效、中医症状积分、肿瘤标志物水平[癌胚抗原(CEA)、鳞状细胞癌相关抗原(SCC)]、不良反应、Karnofsky功能状态量表(KPS)评分、肺癌患者生存质量测定量表(FACT-L)评分。结果观察组疾病控制率、客观缓解率高于对照组(P<0.05);两组治疗后中医症状积分均小于治疗前,且观察组中医症状积分小于对照组(P<0.05);两组治疗后CEA、SCC水平低于治疗前,且观察组CEA、SCC水平低于对照组(P<0.05);两组治疗后KPS、FACT-L评分高于治疗前,且观察组KPS、FACT-L评分高于对照组(P<0.05);观察组不良反应发生率小于对照组(P<0.05)。结论加味二陈汤联合化疗治疗NSCLC近期疗效理想,可进一步减轻患者症状,下调其肿瘤标志物水平,减少药物不良反应,有助于改善患者健康状况及生存质量。

Objective To study the clinical effect of Jiawei Erchen decoction combined with chemotherapy in the treatment of patients with non-small cell lung cancer(NSCLC).Methods A total of 62 patients with NSCLC admitted to the Department of Oncology,Yugan County People's Hospital from March 2019 to March 2022 were selected and divided into control group(31 patients)and observation group(31 patients)according to the random number table method.The control group was treated with chemotherapy,and the observation group was treated with Jiawei Erchen decoction on the basis of the control group.The short-term efficacy,TCM symptom score,tumor marker levels[carcinoembryonic antigen(CEA),squamous cell carcinoma-associated antigen(SCC)],adverse reactions,Karnofky Performance Status(KPS)score,and Functional Assessment of Cancer Therapy-Lung(FACT-L)scale score were compared between the two groups.Results The disease control rate and objective remission rate of the observation group were higher than those of the control group(P<0.05).After treatment,the scores of TCM symptoms in the two groups were lower than those before treatment,and the scores of TCM symptoms in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of CEA and SCC in the two groups were lower than those before treatment,and the levels of CEA and SCC in the observation group were lower than those in the control group(P<0.05).The KPS and FACT-L scores of the two groups after treatment were higher than those before treatment,and the KPS and FACT-L scores of the observation group were higher than those of the control group(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).Conclusion Jiawei Erchen decoction combined with chemotherapy has an ideal short-term effect in the treatment of NSCLC,which can further alleviate the symptoms of patients,down-regulate the level of tumor markers,reduce adverse drug reactions,and help to improve the health status and quality of life of patients.