多囊卵巢综合征合并代谢综合征患者AMH与AFC的相关性及其诊断价值分析

Analysis of Correlation between AMH and AFC in Patients with Polycystic Ovary Syndrome Complicated with Metabolic Syndrome and Its Diagnostic Value

目的:探讨多囊卵巢综合征(PCOS)合并代谢综合征患者抗米勒管激素(AMH)水平与窦卵泡计数(AFC)的相关性及其诊断价值。方法:选择2018年3月—2021年3月瑞金市中医院收治的119例PCOS合并代谢综合征患者为观察组,另选同期体检健康女性60例为对照组。比较两组基础指标、AMH、AFC水平,并分析AMH与AFC及两者与基础指标的相关性。以受试者操作特征(ROC)曲线分析AMH、AFC对PCOS合并代谢综合征的诊断价值。结果:与对照组对比,观察组体重指数(BMI)、腰臀比(WHR)、收缩压(SBP)、舒张压(DBP)、睾酮(T)、空腹血糖(FPG)、甘油三酯(TG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)、AMH、AFC均高于对照组,高密度脂蛋白胆固醇(HDL-C)低于对照组(P<0.05)。Pearson相关性分析显示,AMH、AFC与BMI、WHR、SBP、DBP、T、FPG、TG、FINS、HOMA-IR均呈正相关(P<0.05)。AMH、AFC与HDL-C无关(P>0.05)。Pearson相关性分析显示AMH与AFC呈正相关(P<0.001)。ROC曲线显示,与AMH、AFC单项预测对比,两项联合对PCOS合并代谢综合征发生的诊断价值较高。结论:PCOS合并代谢综合征患者AMH与AFC水平呈正相关且和血脂、血糖、性激素水平密切相关,便于辅助诊断潜在代谢综合征。

Objective:To investigate the correlation between anti-Müllerian hormone(AMH)level and antral follicle count(AFC)in patients with polycystic ovary syndrome(PCOS)complicated with metabolic syndrome and its diagnostic value.Method:A total of 119 patients with PCOS complicated with metabolic syndrome admitted to Ruijin Hospital of Traditional Chinese Medicine from March 2018 to March 2021 were selected as the observation group,and 60 healthy women with medical examination during the same period were selected as the control group.The basic indicators,AMH and AFC were compared between the two groups,and the correlation between AMH and AFC,and their correlation with basic indicators were analyzed.The diagnostic value of AMH and AFC in PCOS complicated with metabolic syndrome was analyzed by receiver-operating characteristic(ROC)curve.Result:Compared with the control group,the body mass index(BMI),waist-to-hip ratio(WHR),systolic blood pressure(SBP),diastolic blood pressure(DBP),testosterone(T),fasting plasma glucose(FPG),triglyceride(TG),fasting insulin(FINS),insulin resistance index(HOMA-IR),AMH and AFC in the observation group were higher than those in the control group,and high density lipoprotein cholesterol(HDL-C)in the observation group was lower than that in the control group(P<0.05).Pearson correlation analysis showed that AMH and AFC were positively correlated with BMI,WHR,SBP,DBP,T,FPG,TG,FINS and HOMA-IR(P<0.05),AMH and AFC were not correlated with HDL-C(P>0.05).Pearson correlation analysis showed that AMH was positively correlated with AFC(P<0.001).ROC curve showed that,compared with the single prediction of AMH and AFC,the combination of AMH and AFC had higher diagnostic value in PCOS complicated with metabolic syndrome.Conclusion:AMH and AFC are positively correlated in patients with PCOS complicated with metabolic syndrome,and they are closely correlated with lipid,blood sugar and sex hormone levels.