小儿腹痛草化学成分、药理作用及临床应用研究概况

Research overview of chemical constituents,pharmacological activity,and clinical application of Swertia patens Burk.

小儿腹痛草是我国云南彝族习用草药,广泛用于治疗小儿痉挛性腹痛、胆囊炎等疾病,主要含有环烯醚萜苷及酮类化合物,其中以獐牙菜苦苷含量最高、药理作用最显著,具有解痉、镇痛、镇静、抗炎、保肝、保胃等作用,与其疏肝清热、和胃止痛的功效密切相关。作为特色显著的儿科民族药,小儿腹痛草相关质量标准尚未健全、应用开发较少。

Swertia patens Burk.is a commonly used herbal medicine of the Yi nationality in Yunnan,China.It is widely used in the treatment of children with spastic abdominal pain,cholecystitis,and other diseases,mainly containing iridoid glycosides and ketone compounds.The highest and most significant pharmacological activity,with antispasmodic,analgesic,sedative,anti-inflammatory,liver-protecting,stomach-protecting,and other effects,is closely related to its effects of soothing the liver,clearing heat,and relieving stomach pain.As a very distinctive pediatric folk medicine,the related quality standards of Swertia patens Burk.have not been perfected,and the development of preparations is relatively lagging.