远志在神经系统退行性疾病中的研究进展

Research Progress of Polygala Tenuifolia in Neurodegenerative Diseases

中药远志具有改善记忆、保护神经、抗痴呆等功效,不仅是古代名医治疗痴呆病症的高频药物,也常用于阿尔茨海默病、帕金森病、肌萎缩性侧索硬化症、颅脑损伤、癫痫、脑缺血等神经系统退行性疾病的临床治疗和研究。远志可通过减少异常蛋白沉积、降低炎症因子释放、减轻氧化应激损伤、调控神经递质等机制发挥保护神经元、改善认知障碍及其他症状的作用。因此,全面了解远志在神经系统退行性疾病中的作用机制,可以为疾病的治疗及药物研发提供新思路。

Traditional Chinese medicine Polygala tenuifolia has the effect of improving memory,protecting nerves,anti-dementia and other effects,which is not only a high-frequency drug to treat dementia by the ancient famous doctors,but also commonly found in the clinical treatment and research of Alzheimer′s disease,Parkinson′s disease,amyotrophic lateral sclerosis,craniocerebral injury,epilepsy,cerebral ischemia and other degenerative diseases of the nervous system at present.Polygala tenuifolia can play a role in protecting neurons,improving cognitive impairment and other symptoms by reducing abnormal protein deposition,decreasing the release of inflammatory factors,alleviating oxidative stress damage,and regulating neurotransmitters.Therefore,a comprehensive understanding of the mechanism of Polygala tenuifolia in neurodegenerative diseases can provide new ideas for the treatment and drug development.