PLIN5的生物学功能及其在心血管疾病中的研究进展

Biological function of perilipin5 and its role in cardiovascular diseases

脂滴包被蛋白(PLINs)又称脂周蛋白/围脂滴蛋白,是脂滴(LDs)表面含量最多的一类参与脂质代谢调节的脂滴相关蛋白家族。PLINs参与LDs的形成、分解、代谢等生物学过程,不同的PLINs在LDs表面具有各自特异的组织分布特征、亚细胞位置、脂质结合特性等功能。其中脂滴包被蛋白5(PLIN5)在富含线粒体的氧化组织如心肌中高度表达,介导LDs与线粒体、内质网等细胞器的相互作用,与多个心血管疾病的发生、发展密切相关。该文从PLIN5的结构、生理学功能及其与心血管疾病关系等方面对国内外相关研究进展作一综述,为进一步研究PLIN5提供参考。

Lipid droplet coated proteins(PLINs),also known as Periprotein/Perilipodropin,are a family of lipid droplet-related proteins participate in the regulation of lipid metabolism with the most content on the surface of lipid droplets(LDs).PLINs are participate in the biological processes of Lipid droplets formation,decomposition,and metabolism.Different PLINs have their own specific functions on the surface of lipid droplets,such as tissue distribution characteristics,subcellular location,and lipid binding characteristics.PLIN5 is highly expressed in mitochondria-rich oxidized tissues such as myocardium,mediating the interaction of LDs with mitochondria,endoplasmic reticulum and other organelles,and is closely related to the occurrence and development of multiple cardiovascular diseases(CVD).This paper reviews the structure,function and lipid regulation of PLIN5,CVD research and provided references for further researches on PLIN5.