盐酸米诺环素辅助显微根管联合牙周组织再生术治疗牙周牙髓联合病变伴畸形根面沟的效果观察

Efficacy of minocycline hydrochloride combined with microscopic root canal and periodontal tissue regeneration in the treatment of endodontic-periodontal lesions with root groove deformity

目的探讨盐酸米诺环素辅助显微根管联合牙周组织再生术治疗牙周牙髓联合病变伴畸形根面沟的效果。方法选取2020年4月—2022年1月常州市中医医院收治的102例(共102颗患牙)牙周牙髓联合病变伴畸形根面沟患者,以随机数字表法分为对照组和研究组,每组51例。对照组接受显微根管联合牙周组织再生术治疗,研究组在对照组基础上给予盐酸米诺环素治疗。对比两组手术成功率、牙周相关指标、炎症因子、咀嚼功能评分、疼痛情况及并发症。结果研究组术后1年手术成功率(90.20%)高于对照组(72.55%)(P<0.05)。研究组治疗前后龈沟出血指数、探诊深度、牙石指数、菌斑指数、C反应蛋白、肿瘤坏死因子、白细胞介素-17、咀嚼功能评分、视觉模拟评分的差值均高于对照组(P<0.05)。两组并发症总发生率比较,差异无统计学意义(P>0.05)。结论盐酸米诺环素辅助显微根管联合牙周组织再生术治疗牙周牙髓联合病变伴畸形根面沟患者疗效确切,可改善牙周组织状态,减轻炎症反应、疼痛。

Objective To investigate the efficacy of minocycline hydrochloride combined with microscopic root canal and periodontal tissue regeneration in the treatment of endodontic-periodontal lesions with root groove deformity.Methods A total of 102 patients(102 teeth in total)with endodontic-periodontal lesions combined with root groove deformity in our hospital from April 2020 to January 2022 were selected and divided into the control group and the study group by the random number table method,with 51 cases in each group.The control group was treated with microscopic root canal and periodontal tissue regeneration,and the study group was additionally treated with minocycline hydrochloride.The success rate of surgery,periodontal indices,levels of inflammatory factors,masticatory function scores,pain and complications were compared between the two groups.Results The 1-year success rate of surgery in the study group(90.20%)was higher than that in the control group(72.55%)(P<0.05).The differences of sulcus bleeding index,probing depth,calculus index,plaque index,levels of C-reactive protein,tumor necrosis factor-α,and interleukin-17,masticatory function scores,and Visual Analogue Scale scores before and after the treatment in the study group were greater than those in the control group(P<0.05).There was no difference in the overall incidence of complications between the two groups(P>0.05).Conclusions Minocycline hydrochloride combined with microscopic root canal and periodontal tissue regeneration is effective in the treatment of patients with endodontic-periodontal lesions with root groove deformity.It improves the periodontal health and ameliorates inflammation and pain.