蓝芩口服液联合抗菌药物治疗小儿肺炎的临床疗效及对患儿血清白细胞介素-2和肿瘤坏死因子-α水平的影响

Clinical efficacy of Lanqin oral liquid combined with antibiotics in the treatment of infantile pneumonia and its influence on serum levels of interleukin-2 and tumor necrosis factor-αin children

目的探究蓝芩口服液联合抗菌药物治疗小儿肺炎的临床疗效及对患儿血清白细胞介素-2(IL-2)、肿瘤坏死因子-α(TNF-α)水平的影响。方法选取2018年10月至2021年4月于德兴市人民医院儿科确诊的80例小儿肺炎患儿作为研究对象,随机分为观察组与对照组,每组40例。对照组采用安美汀联合头孢噻甲羧肟静脉滴注治疗,观察组在对照组治疗基础上加用蓝芩口服液治疗,比较两组临床疗效、肺部体征消失时间、扁桃体红肿消失时间、鼻塞流涕消失时间、炎症因子水平、不良反应发生情况。结果观察组治疗总有效率为97.50%,明显高于对照组的80.00%,差异有统计学意义(P<0.05);治疗后,两组IL-2水平均高于治疗前,TNF-α水平均低于治疗前,且观察组血清IL-2水平高于对照组,TNF-α水平低于对照组,差异有统计学意义(P<0.05);治疗后,观察组肺部体征消失时间、扁桃体红肿消失时间、鼻塞流涕消失时间均短于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为7.50%,低于对照组的25.00%,差异有统计学意义(P<0.05)。结论蓝芩口服液联合安美汀及头孢噻甲羧肟治疗小儿肺炎疗效确切,不仅可有效缓解患儿的临床症状,缩短治疗时间,还可减少不良反应,值得临床推广应用。

Objective To investigate the clinical efficacy of Lanqin oral liquid combined with antibiotics in the treatment of infantile pneumonia and its influence on serum levels of interleukin-2(IL-2)and tumor necrosis factor-α(TNF-α)in children.Methods 80 pediatric pneumonia patients diagnosed in the department of Pediatrics of Dexing People's Hospital from October 2018 to April 2021 were selected as the study subjects,and they were randomly divided into the observation group and the control group,with 40 cases in each group.The control group was treated with ametine combined with ceftaxime intravenous infusion,and the observation group was treated with Lanqin oral liquid on the basis of the treatment of the con-trol group.The clinical efficacy,the disappearance time of pulmonary signs,the disappearance time of tonsil redness and swelling,the disappearance time of nasal congestion and runny nose,the level of inflammatory factors and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate in the observation group was 97.50%,which was significantly higher than 80.00%in the control group,the difference was statistically significant(P<0.05).After treatment,the level of IL-2 of the two groups were higher than before treatment,and the level of TNF-αof the two groups was lower than before treatment,and the serum level of IL-2 in the observation group was higher than that in the control group,and the level of TNF-αwas lower than that in control group,and the differences were statistically significant(P<0.05).After treatment,the disappearance time of pulmonary signs,tonsil swelling and nasal congestion in observation group was shorter than that in control group,and the dif-ference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 7.50%,which was lower than 25.00%in the control group,and the difference was statistically significant(P<0.05).Conclusion Lanqin oral liquid combined with ametine and ceftaxime is effective in the treatment of pediatric pneumonia,which can not only effectively relieve the clinical symptoms of children,shorten the treatment time,but also reduce adverse reactions,which is worthy of clinical promotion and application.