血清OPG/RANKL之值与高血压左心室厚度的相关性研究

Study of the correlation between serum OPG/RANKL ratio and left ventricular thickness in hypertension

目的:分析血清骨保护素/破骨细胞分化因子(OPG/RANKL)之值与高血压左心室厚度的相关性。方法:将87例研究对象分为健康组(27例)和高血压组(60例),其中高血压组通过测定左心室厚度又分为无左心室肥厚组(30例)与左心室肥厚组(30例),所有研究者均测定血清OPG、RANKL水平,并计算OPG/RANKL之值。结果:与健康组相比,高血压组的血清OPG水平、血清OPG/RANKL之值均显著升高,血清RANKL水平显著降低,差异均具有统计学意义(P<0.05);与高血压无左心室肥厚组相比,高血压左心室肥厚组的血清OPG水平、血清OPG/RANKL之值均显著升高,血清RANKL水平显著降低,差异均具有统计学意义(P<0.001)。相关性分析显示,室间隔厚度与血清OPG水平及OPG/RANKL之值呈正相关(r=0.685、0.636,P<0.001),与血清RANKL水平呈负相关(r=-0.546,P<0.001)。进一步行多元线性回归分析显示,血压水平升高、血清OPG/RANKL之值增高是室间隔增厚的重要因素(B=0.076,P<0.001)。结论:高血压患者测定血清OPG/RANKL之值对其左室厚度评估可能具有一定临床意义。

Objective:To analyze the correlation between serum OPG/RANKL ratio and hypertension complicated with left ventricular hypertrophy.Methods:87 research objects were divided into a healthy group(27 cases)and a hypertensive group(60 cases),in which the hypertensive group was subdivided into group without left ventricular hypertrophy(30 cases)and a group with left ventricular hypertrophy(30 cases).All research objects had to be detected the level of serum OPG、RANKL,then calculated the OPG/RANKL ratio.Results:Compared with the healthy group,serum OPG levels and serum OPG/RANKL ratio were significantly higher and serum RANKL levels were significantly lower in the hypertensive group,and the difference was statistically significant(P<0.05).Compared with the hypertensive group without left ventricular hypertrophy,the hypertensive left ventricular hypertrophy group showed a statistically significant increase in serum OPG levels,serum OPG/RANKL ratio,and a statistically significant decrease in serum RANKL levels(P<0.001).There was a positive linear correlation between interventricular septal thickness and the level of serum OPG、OPG/RANKL ratio(r=0.685,0.636;P<0.001),and negativery correlated with serum RANKL levels(r=-0.546,P<0.001).Multiple linear regression analysis showed that blood pressure elevated and serum OPG/RANKL ratio were an important factors to the increased thickness of interventricular septum(B=0.076,P<0.001).Conclusion:The serum OPG/RANKL ratio indicated that it might be used as a laboratory indicator for the evaluation of hypertensions left ventricula.