治疗胃溃疡中药的用药规律及作用机制探究

Exploration of Chinese Herbal Medication Rules and Action Mechanism of Gastric Ulcer

本文基于文献数据挖掘分析了中药治疗胃溃疡的用药规律及作用机制,结果发现该机制涉及多成分、多靶点和多信号通路。治疗胃溃疡的前10味高频中药分别是半夏、甘草、白芍、党参、茯苓、延胡索、白术、陈皮、黄芪和柴胡。在高频药物“党参-半夏-白芍-甘草”组合中,有效活性组分有127个,药物作用靶点有252个。在胃溃疡疾病的601个靶点中,两者的共有作用靶点80个,其中治疗胃溃疡的关键靶点可能是STAT3、JUN、TP53、TNF、MAPK3和IL6等,而信号通路则涉及恶性肿瘤、AGE-RAGE、HIF-1、NF-κB等途径。

This paper analyzed the medication rules of traditional Chinese medicine(TCM)in the treatment of gastric ulcer(GU)and its possible mechanism based on literature data mining.The results found that its mechanism may involve multi-component,multi-target and multi-signal pathways.The top ten high-frequency drugs were Banxia,Gancao,Baishao,Dangsheng,Fuling,Yanhusuo,Baizhu,Chenpi,Huangqi..In combination of‘Dangshen-Banxia-Baishao-Gancao’,127 effective active components and 252 drug targets were found.It shared 80 out of 601 targets in GU disease.The key target protein for GU treatment may be STAT3,Jun,TP53,TNF,MAPK3 and IL6.Furthermore,the signal pathway involves cancer,AGE-RAGE,HIF-1 and NF-κB,etc.