中性粒细胞哮喘发病机制及治疗的研究进展

Research progress of pathogenesis and treatment of neutrophilic asthma

支气管哮喘(哮喘)是一种以慢性气道炎症和气道高反应性为特征的异质性疾病。其中,以中性粒细胞性气道炎症为特点的哮喘表型称为中性粒细胞哮喘,临床上多表现为重症难治性哮喘,对激素治疗反应差。研究表明,多种细胞因子及炎症介质参与了中性粒细胞哮喘的发病过程。近年来,随着对中性粒细胞哮喘发病机制认识的深入,针对该表型的哮喘治疗方法成为研究的新热点。本文就中性粒细胞哮喘的发病机制及治疗的研究进展进行综述。

Bronchial asthma(asthma)is a heterogeneous disease characterized by chronic airway inflammation and airway hyperresponsiveness.The asthma phenotype featured by neutrophil airway inflammation is called neutrophilic asthma,which is characterized by severe refractory asthma and poor response to hormone therapy.It has been found that a variety of cytokines and inflammatory mediators are involved in the pathogenesis of neutrophilic asthma.In recent years,with the in-depth understanding of the pathogenesis of neutrophilic asthma,the treatment of this phenotype has become a new focus of research.This article reviews the research progress in the pathogenesis and treatment of neutrophilic asthma.