摘要
支气管哮喘(哮喘)是一种异质性疾病,其主要特征在于慢性气道炎症。根据病理生理机制的多样性,哮喘可以分为不同的内型。非2型哮喘是重度哮喘患者的重要内型,其发病机制复杂,疾病负担沉重,常出现皮质类固醇抵抗,治疗效果欠佳。近年来,生物靶向治疗及支气管热成形术在重度非2型哮喘的治疗中发挥重大作用。本文就重度非2型哮喘的临床特征、发病机制及治疗现状进行系统阐述。
Bronchial asthma(asthma)is a highly heterogeneous disease featured by chronic airway inflammation.Asthma can be divided into several endotypes according to the varying pathophysiogical mechanisms.Non-type 2 asthma is an important endotype with complex mechanism,resulting in corticosteroid resistance,which negatively affects the treatment and brings heavy financial burden.In recent years,biotarget therapies and bronchial thermoplasty have played crucial roles in the treatment of severe non-type 2 asthma.The present article systematically reviewed the clinical features,mechanisms,and current therapies of non-type 2 asthma.
作者
周楚艺
苏新明
Zhou Chuyi;Su Xinming(Department of Respiratory and Critical Care Medicine,the First Hospital of China Medical University,Shenyang 110000,China)
出处
《国际呼吸杂志》
2023年第12期1484-1488,共5页
International Journal of Respiration
基金
国家自然科学基金(82170038)。
关键词
哮喘
非2型哮喘
病理生理机制
治疗
Asthma
Non-type 2 asthma
Pathological mechanism
Therapy
