骨肌系统内源性再生修复的研究进展

Research progress on endogenous regeneration and repair of the musculoskeletal system

目的探讨骨肌系统内源性再生修复的最新研究进展。方法在美国国家生物技术信息中心、Web of Science、中国知网、万方数据等中英文数据库中,检索2023年9月之前公开发表的有关骨、软骨、椎间盘及肌肉(腱)等组织内源性再生修复研究的相关文献,共检索到文献348篇,按纳入和排除标准最终纳入49篇文献,对内源性再生修复在骨肌系统中的研究情况及其可能的机制进行总结。结果在骨、软骨、椎间盘、肌肉、肌腱等组织中均存在内源性再生修复;内源性再生修复可通过组织工程支架材料引入相关生物学信号(如归巢信号等),或通过单纯生物工程支架系统来促进相关组织的再生修复;内源性再生修复的机制可能涉及受体和黏附分子的表达、与内皮细胞的作用以及免疫系统的诱导。结论内源性再生修复在骨肌系统的研究取得了显著的进展。促进组织的内源性再生修复是再生医学中一种很有前途的治疗方式,未来临床应用前景广泛。

Objective This study aims to summarize the latest progress of endogenous regeneration and repair in musculoskeletal system and its possible mechanism.Methods Literature on the study of endogenous regeneration and repair in bone,cartilage,intervertebral disc,and muscle(tendon)published before September 2023 was searched in NCBI,Web of Science,CNKI,and Wanfang databases,and 348 studies were retrieved.According to inclusion and exclusion criteria,49 studies were finally included and used to analyze the possible mechanism of endogenous regeneration and repair in the musculoskeletal system.Results Endogenous regeneration and repair was conducted in bone,cartilage,intervertebral disc,muscles,and tendon to promote the regeneration and repair of related tissues by introducing relevant biological signals(such as homing signals,etc.)or single bioengineering scaffold.The mechanism of endogenous regeneration and repair may involve the expression of receptors and adhesion molecules,the interaction with endothelial cells,and the induction of the immune system.Conclusion The research of endogenous regeneration and repair in the musculoskeletal system has made great progress.Promoting endogenous regeneration and repair of tissues is a promising method in regenerative medicine and has a broad prospect in clinical application in the future.