肠球菌素的分类、合成及抗菌机制

Classification, Synthesis and Antibacterial Mechanism of Enterocin

肠球菌(enterococcus)属于乳酸菌(LAB)一类,广泛分布于各种环境中,是人类和动物肠道正常菌群的一部分。虽然近年来肠球菌逐渐进化出引起院内感染的致病菌株,但非致病菌株仍被广泛用作益生菌和饲料添加剂。肠球菌可以产生肠球菌素,肠球菌素被认为是杀死或抑制其他微生物生长的核糖体肽。本文就肠球菌素的分类、合成、抗菌机制及应用进行综述,并对未来的研究前景进行展望。

Enterococcus,which belongs to the class of lactic acid bacteria(LAB),is widely distributed in a variety of environments and is part of the normal intestinal flora of humans and animals.Although enterococcus has gradually evolved pathogenic strains causing nosocomial infections in recent years,non-pathogenic strains are still widely used as probiotics and feed additives.Enterococcus can produce enterocin,which are ribosomal peptides that are thought to kill or inhibit the growth of other microorganisms.In this paper,the classification,synthesis,antibacterial mechanism and application of enterocin are reviewed,and the future research prospects are also prospected.