Shed a New Light on Spinal Cord Injury-induced Permanent Paralysis with the Brain-spine Interface

How to deal with severe spinal cord injuries(SCI)?This question remains an everlasting challenge for neurologists.Recent innovative therapies such as neuromodulation,which targets the surviving tissue,have shown the potential to restore cognitive functions in patients with severe SCI after rehabilitation[1,2].These therapies might enable SCI patients to sustain active movements during rehabilitation training to enhance the reorganization of the neuronal pathways,however,the complete recovery of body movement functions was still not reached with these therapies.A characteristic feature of SCI is the impairment of neural information communication between the neurons in the spinal cord and the brain,which are responsible for regulating body movement.Brain-computer interfaces(BCIs)have been successfully applied in dealing with movement dysfunction by establishing a direct connection between brain cortical activity and electrical muscle stimulation,thereby restoring limb function in cases of paralysis[2].