肌少-骨质疏松症的研究进展

Research progress on osteosarcopenia

肌少—骨质疏松症是一种肌少症和骨质疏松症并存的老年综合征。发病机制涉及遗传基因、骨骼-肌肉机械作用、内分泌调节机制、分子信号通路等多种因素。在临床实践中,除了需综合评估危险因素外,还需筛查骨密度、肌肉力量、肌肉质量及机体整体功能情况。干预措施主要包括运动疗法、营养支持和药物等。

Osteosarcopenia is a geriatric syndrome referring to the co-existence of osteoporosis and sarcopenia.Its pathogenesis involves factors such as genetics,mechanics of the musculoskeletal system,endocrine regulatory mechanisms and molecular signaling pathways.In clinical practice,aside from comprehensive assessment of risk factors,screening of bone density,muscle strength,muscle mass and the overall body function must also be undertaken.Intervention measures primarily include therapeutic exercise,nutritional support and drugs.