CD20^(+)T淋巴细胞在多发性硬化中的作用及机制研究

CD20^(+)T cells in multiple sclerosis

CD20是一种经典的B细胞标志物,但近年来有研究发现,除B细胞外,部分CD3^(+)T淋巴细胞亚型也微弱表达CD20分子,并且在多发性硬化(MS)的发病机制中发挥重要的促炎作用,抗CD20药物选择性清除CD20^(+)T细胞后,可有效抑制炎性疾病活动。虽然CD20^(+)T细胞受到越来越多的关注,但目前人们对其的理解仍处于起步阶段,文中就该细胞亚群的最新研究进展及其在MS中的作用作一综述。

CD20 is a classic marker expressed by B cells.However,recent studies have found that CD20 is also dimly expressed on a small subset of CD3^(+)T cells,and the CD20^(+)T cells play an important proinflammatory role in multiple sclerosis(MS).Anti-CD20 monoclonal antibodies selectively deplete CD20^(+)T cells and effectively suppress inflammatory disease activity.Although CD20^(+)T cells have received increasing attention,the understanding of these cells is currently still in its infancy.This article provides an overview of the current knowledge about advanced progress of CD20^(+)T cells as well as their roles in MS.