炎症性肠病药物治疗的沿革与前瞻

History and prospect of medical treatment of inflammatory bowel disease

炎症性肠病是一组病因未明的慢性非特异性炎症性疾病,可累及整个消化道。最早的文献记载距今约两百年,但直到上世纪中叶才开始逐步认识这一疾病。几十年间,炎症性肠病的治疗实现了从“无药可治”到生物制剂时代的飞跃。如今,氨基水杨酸制剂、糖皮质激素、免疫抑制剂、生物制剂及小分子药物在炎症性肠病治疗中的效果与经验日渐丰富,本文就炎症性肠病和相关药物的选择作一综述,为推动新药研发和临床治疗提供更多的参考。

Inflammatory bowel disease(IBD)is a type of chronic,non-specific inflammatory disorders of unknown etiology,which can involve the entire gastrointestinal tract.The disease was first documented around two hundred years ago,but it wasn't until the middle of the last century that people began to recognize it gradually.Over the decades,the treatment of IBD has made a leap from"no cure"to the age of biological agents.Today,there is growing experience with aminosalicylic acid agents,glucocorticoids,immunosuppressants,biologics and small molecule drugs in the treatment of IBD,This article reviews IBD and the selection of related drugs to provide more references for promoting the development of new drugs and clinical treatment.