度拉糖肽对2型糖尿病血糖控制的影响因素分析

目的分析度拉糖肽对2型糖尿病血糖控制的影响因素。方法回顾性分析2018年1月至2022年12月采用度拉糖肽治疗的2型糖尿病患者290例,收集患者治疗前后的临床资料,分析度拉糖肽血糖控制效果的影响因素。结果度拉糖肽治疗8周后,血糖控制良好223例,血糖控制不佳67例。血糖控制良好组治疗前单核细胞计数、HOMA-β以及血清钠水平比血糖控制不佳组高,糖尿病周围神经病变率、C-反应蛋白、甘油三酯以及ALT水平明显比血糖控制不佳组低,差异有统计学意义(P<0.05);二元Logistic回归分析显示,度拉糖肽治疗前HOMA-β、血清钠、C-反应蛋白、甘油三酯以及ALT水平可影响2型糖尿病的血糖控制效果(P<0.05)。结论度拉糖肽治疗后大部分2型糖尿病患者均能获得良好的血糖控制效果,同时HOMA-β、血清钠、C-反应蛋白、甘油三酯以及ALT水平为影响度拉糖肽治疗后血糖控制效果的因素,在为患者制定治疗方案时需注意。

Objective To analyze the influence of dulaglutide on blood glucose control in type 2 diabetes.Methods 290 patients with type 2 diabetes who were admitted to Lishui People's Hospital from January 2018 to December 2022 and treated with dulaglutide were retrospectively selected.The clinical data before treatment were collected,the blood glucose control effect after 8 weeks of dulaglutide treatment was evaluated,and the factors influencing the blood glucose control effect of dulaglutide were further analyzed.Results After 8 weeks of treatment with dulaglutide,223 cases had good blood sugar control,while 67 cases had poor blood glucose control.In the well-controlled blood glucose group,monocyte count,Homeostatic Model Assessment of Beta Cell Function(HOMA-β)and the serum sodium level were higher compared to the poorly controlled blood glucose group before treatment,the peripheral neuropathy rate of diabetes,C-reactive protein,triglyceride and alanine aminotransferase(ALT)levels were significantly lower than that of the poorly controlled group(P<0.05).After controlling for confounding factors using a binary logistic regression model,it was found that HOMA-βbefore dulaglutide treatment,serum sodium,C-reactive protein,triglyceride and ALT levels could affect the effect of blood glucose control in type 2 diabetes(P<0.05).Conclusion Most patients with type 2 diabetes can achieve good blood glucose control effect after treatment with dulaglutide,and HOMA-β,serum sodium,C-reactive protein,triglycerides,and ALT levels are factors that affect the efficacy of glycemic control after treatment with dulaglutide.Attention should be paid when formulating treatment plans for patients.