鼻疗法治疗偏头痛发作期的用药规律研究

Medication Rule of Nasal Therapy for Migraine Attack

目的:基于数据挖掘探讨鼻疗法治疗偏头痛发作期的用药规律。方法:检索中国知网数据库(CNKI)、万方医学网、维普中文科技期刊数据库(VIP),双人筛选文献并录入数据,建立数据库。采用数据挖掘技术(频数分析、关联规则、聚类分析)对纳入文献药物进行分析。结果:共筛选出鼻疗法治疗偏头痛发作期的临床研究文献38篇,涉及中药处方38首和32味中药,药物总使用频次181次。7味中药使用频次≥6次,依次是川芎、冰片、白芷、细辛、羌活、薄荷、制远志,药物功效以解表药、活血化瘀药、开窍药、温里药最为多见,性味以辛温多见,药物归经多见肺经。关联规则分析中,支持度大于40%,得出关联药对5组,均以川芎为后项,配伍白芷、冰片、细辛。核心药物聚类分析大致分为2个类别。结论:通过数据挖掘鼻疗法治疗偏头痛发作期的用药规律,一定程度上为临床用药及新药研发提供思路。

Objective:To explore the medication rules of nasal therapy for migraine attacks based on data mining technology.Methods:China National Knowledge Infrastructure(CNKI),Wanfang Medical Network,VIP Chinese Science and Technology Journal Database(VIP)were searched to establish the database.Data mining techniques(frequency analysis,association rules,cluster analysis)were used to analyze the included drugs.Results:A total of 38 clinical studies of nasal therapy in the treatment of migraine attacks were screened out,involving 38 prescriptions and 32 traditional Chinese medicine prescriptions,and the total frequency of drug use was 181 times.There were 7 kinds of traditional Chinese medicine with frequency≥6:Chuanxiong,borneol,Angelica Dahurica,asarum,notopterygium root,mint,and prepared polygala.The most popular drugs were antipyretic,invigorating blood circulation and eliminating stasis,awaking,interior-warming.The most popular properties and flavor were pungent-warm,and the main channels were lung.The analysis of association rules showed there were 5 groups of association drugs,with Chuanxiong as the last term,and with Angelica dahurica,borneol,and asarum.Cluster analysis of core drugs could be divided into two categories.Conclusion:Through data mining the medication rules of nasal therapy for the treatment of migraine attacks,it will provide ideas for clinical medication and new drug research and development.